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N-acylethanolamine acid amidase

Summary

Gene Symbol

Naaa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67111

PubChem

67111

Alliance of Genome Resources

MGI:1914361

Annotation

Keyword

3D-structure
Autocatalytic cleavage
Fatty acid metabolism
Glycoprotein
Hydrolase
Lipid degradation
Lysosome
Membrane
Proteomics identification
Reference proteome
Signal
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9D7V9	Acylsphingosine deacylase NAAA N-acylsphingosine amidohydrolase-like
G3XA18	Acylsphingosine deacylase NAAA
Q3V023	Acylsphingosine deacylase NAAA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acylethanolamine metabolic process	ISO ISS
fatty acid metabolic process	IEA ISO ISS
N-acylphosphatidylethanolamine metabolic process	ISO ISS
lipid catabolic process	IEA
sphingosine metabolic process	ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

organic substance catabolic process [inference]

lipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	ISO ISS
lysosome	IDA ISO ISS	29514215
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA-binding transcription factor binding	IEA ISO
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IBA ISO
ceramidase activity
fatty acid amide hydrolase activity	ISO ISS
N-acylsphingosine amidohydrolase activity	ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

binding [inference]

protein binding [inference]

transcription factor binding [inference]

DNA-binding transcription factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acylethanolamine-hydrolyzing acid amidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
N-acylsphingosine amidohydrolase activity
ceramidase activity
fatty acid metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity
lipid metabolic process

Displaying 1 entry
InterPro
Acid ceramidase, N-terminal

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

RHEA:17505

H₂O + N-(long-chain fatty acyl)ethanolamine

a long-chain fatty acid + ethanolamine

Enzyme

3.5.1.60

PMID

4055775

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006218
Gene Name: N-acylethanolamine acid amidase

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	27163		HGNC:736	HUMAN76016
Caenorhabditis elegans	190304		WB:WBGene00021917
Xenopus tropicalis	448239		Xenbase:XB-GENE-1006650
Rattus norvegicus	497009	10116_1:0042fd	RGD:1307267	RATNO08847
Macaca mulatta	700991			MACMU37716
Pan troglodytes	739402			PANTR33712
Monodelphis domestica	100024438			MONDO25974
Equus caballus	100057831			HORSE31304
Ciona intestinalis	100185070			CIOIN01042
Taeniopygia guttata	100223326			TAEGU23744