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squalene epoxidase

Summary

Gene Symbol

SQLE

Aliases

squalene monooxygenase

Organism

Homo sapiens (human)

External Links

NCBI Gene

6713

HGNC

11279

KEGG Gene ID

hsa:6713

PubChem

6713

Alliance of Genome Resources

HGNC:11279

Annotation

Keyword

3D-structure
Endoplasmic reticulum
FAD
Lipid metabolism
Membrane
Microsome
Oxidoreductase
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q14534	Squalene epoxidase
Q5HYI4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to organic substance	IEA
lipid droplet formation	IMP	29765154
regulation of cell population proliferation	IMP	29765154
sterol biosynthetic process	IBA IDA NAS	30626872 9286711
cholesterol metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet formation

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

response to stimulus [inference]

response to chemical [inference]

response to organic substance

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell population proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA	30626872
endoplasmic reticulum	IBA
endoplasmic reticulum membrane
membrane	IDA	30626872

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
squalene monooxygenase activity	IBA IDA NAS	30626872 9286711
protein binding	IPI	29765154 32296183
FAD binding	IDA	30626872

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000104549

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00511

Name

squalene monooxygenase [EC:1.14.14.17]

References

17852349

Rhea

RHEA:25282

O₂ + squalene

H₂O + H⁺ + (S)-2,3-epoxysqualene

Enzyme

1.14.14.17

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 42 in total

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DO ID	Disease Name	Source
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET
DOID:0110044	Alzheimer's disease 11	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001413
Gene Name: squalene epoxidase

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103187848		CALMI37661
Danio rerio	799528	ZFIN:ZDB-GENE-071004-98	DANRE11515
Danio rerio	565329	ZFIN:ZDB-GENE-060503-750
Astyanax mexicanus	103022030		ASTMX01828
Ictalurus punctatus	108256332		ICTPU18452
Electrophorus electricus	113577069		ELEEL19271
Salmo salar	106579093		SALSA107145
Salmo salar	106605546		SALSA126734
Salmo trutta	115177539		SALTR84155
Salmo trutta	115181075		SALTR44493

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements