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steroid 5 alpha-reductase 2

Summary

Gene Symbol

SRD5A2

Aliases

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6716

HGNC

11285

KEGG Gene ID

hsa:6716

PubChem

6716

Alliance of Genome Resources

HGNC:11285

Annotation

Keyword

3D-structure
Disease variant
Lipid metabolism
Microsome
NADP
Oxidoreductase
Pseudohermaphroditism
Reference proteome
Sexual differentiation
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P31213	5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2 Type II 5-alpha reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
steroid biosynthetic process	IBA
androgen biosynthetic process	TAS
steroid catabolic process	IEA
cell-cell signaling	TAS	1944596
androgen metabolic process	IDA	1944596

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

dibenzo-p-dioxin metabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound metabolic process [inference]

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

organic hydroxy compound metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

cellular developmental process [inference]

cell differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

bone development

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

system development [inference]

reproductive system development [inference]

male genitalia development

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to lipid [inference]

response to ketone [inference]

response to testosterone

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone

response to ketone [inference]

response to testosterone

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
neuronal cell body	IEA
cell body fiber	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body fiber

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS
3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA
protein binding	IPI	32296183 33961781
testosterone dehydrogenase [NAD(P)] activity	IDA	10898110
amide binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

testosterone dehydrogenase [NAD(P)] activity

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

testosterone dehydrogenase [NAD(P)] activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

enone reductase activity [inference]

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
3-oxo-5-alpha-steroid 4-dehydrogenase activity
brassinosteroid biosynthetic process
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity

Displaying **all 2** entries
InterPro
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase

KEGG BRITE Database

Orthology

K12344

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]

References

Rhea

RHEA:54384

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

RHEA:21952

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10892	hypospadias	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000033	Ambiguous genitalia, male
HP:0000046	Small scrotum
HP:0000048	Bifid scrotum
HP:0000051	Perineal hypospadias
HP:0000054	Micropenis
HP:0000062	Ambiguous genitalia
HP:0000144	Decreased fertility
HP:0000818	Abnormality of the endocrine system

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:753	46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
OMIM:264600	46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency

PubChem Disease

GHR Health Conditions

MedGen Diseases

3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency

OMIM Phenotypes

PSEUDOVAGINAL PERINEOSCROTAL HYPOSPADIAS; PPSH

KEGG Diseases

46,XY disorder of sex development due to testosterone secretion defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002521
Gene Name: steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	6715	WB:WBGene00009635
Xenopus tropicalis	6716	Xenbase:XB-GENE-940949
Rattus norvegicus	64677		RATNO35223
Mus musculus	94224		MOUSE21229
Sus scrofa	397048		PIGXX22302
Canis lupus familiaris	403715		CANLF05022
Bos taurus	527024		BOVIN02187
Danio rerio	550388		DANRE05944
Equus caballus	100070655		HORSE09564
Ornithorhynchus anatinus	100078235		ORNAN27915

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements