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SRP receptor subunit alpha

Summary

Gene Symbol

SRPRA

Organism

Homo sapiens (human)

External Links

NCBI Gene

6734

PubChem

6734

Alliance of Genome Resources

HGNC:11307

JoGo

SRPRA

TogoVar

SRPRA

Annotation

Keyword

3D-structure
Alternative splicing
Endoplasmic reticulum
GTP-binding
Membrane
Phosphoprotein
Proteomics identification
Receptor
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P08240	Docking protein alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cotranslational protein targeting to membrane	TAS	2827661
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	NAS	16439358
intracellular protein transport	IEA
protein targeting to ER	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein targeting to ER

protein transport [inference]

intracellular protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein targeting to ER

protein transport [inference]

intracellular protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein targeting to ER

protein transport [inference]

intracellular protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein targeting to ER

protein transport [inference]

intracellular protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signal recognition particle receptor complex	EXP	16439358
endoplasmic reticulum membrane	TAS	2827661
endoplasmic reticulum membrane	IBA
membrane	NAS	16439358
membrane	IDA	22375059

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

signal recognition particle receptor complex

endoplasmic reticulum protein-containing complex [inference]

signal recognition particle receptor complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
GTPase activity	IBA
signal recognition particle binding	IBA
protein binding	IPI	33053321
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

signal recognition particle binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal recognition particle

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
GTP binding
SRP-dependent cotranslational protein targeting to membrane
nucleotide binding
protein targeting to ER
signal recognition particle binding

Displaying **all 8** entries
InterPro
AAA+ ATPase domain
Longin-like domain superfamily
P-loop containing nucleoside triphosphate hydrolase
SRP/SRP receptor, N-terminal
Signal recognition particle SRP54, N-terminal domain superfamily
Signal recognition particle SRP54, helical bundle
Signal recognition particle receptor, alpha subunit, N-terminal
Signal recognition particle, SRP54 subunit, GTPase domain