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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
signal transducer and activator of transcription 1
Summary
- Gene Symbol
-
- STAT1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- Acetylation
- Activator
- Alternative splicing
- Antiviral defense
- Coiled coil
- Cytoplasm
- DNA-binding
- Direct protein sequencing
- Disease variant
- Host-virus interaction
- Isopeptide bond
- Methylation
- Nucleus
- Phosphoprotein
- Reference proteome
- SH2 domain
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P42224 |
|
Gene Ontology (GO)
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein-containing complex | ||
| ISGF3 complex | ||
| nucleoplasm | ||
| RNA polymerase II transcription regulator complex | ||
| dendrite |
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Signal transducer and activator of transcription
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine-mediated signaling pathway |
| receptor signaling pathway via JAK-STAT |
| regulation of cell population proliferation |
| response to peptide hormone |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111944 | immunodeficiency 31B | |
| DOID:0111945 | immunodeficiency 31A | |
| DOID:0111946 | immunodeficiency 31C | |
| DOID:1612 | breast cancer | |
| DOID:1883 | hepatitis C | |
| DOID:2154 | nephroblastoma | |
| DOID:234 | colon adenocarcinoma | |
| DOID:2526 | prostate adenocarcinoma | |
| DOID:2841 | asthma | |
| DOID:2945 | severe acute respiratory syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20846 | MGI:103063 | MOUSE27805 | ||
| 25124 | RGD:3771 | |||
| 30768 | ZFIN:ZDB-GENE-980526-499 | |||
| 42428 | FB:FBgn0016917 | |||
| 178465 | WB:WBGene00013111 | |||
| 367264 | RGD:1305747 | |||
| 368481 | ZFIN:ZDB-GENE-030616-23 | |||
| 396655 | PIGXX09684 | |||
| 398324 | Xenbase:XB-GENE-864837 | |||
| 459834 | 9598_0:000cd2 | PANTR29389 |
