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MIRAGE
signal transducer and activator of transcription 3
Summary
- Gene Symbol
-
- STAT3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative splicing
- Coiled coil
- Cytoplasm
- DNA-binding
- Diabetes mellitus
- Disease variant
- Dwarfism
- Host-virus interaction
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- SH2 domain
- Transcription regulation
- Proteins
| UniProt | Protein Name |
|---|---|
| P40763 |
|
| A0A7I2V395 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| energy homeostasis | ||
| positive regulation of tumor necrosis factor production | ||
| response to leptin | ||
| temperature homeostasis | ||
| positive regulation of interleukin-10 production |
GO Hierarchy
- leptin-mediated signaling pathway
- interleukin-15-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- interleukin-9-mediated signaling pathway
- interleukin-11-mediated signaling pathway
- interleukin-23-mediated signaling pathway
- interleukin-6-mediated signaling pathway
- interleukin-10-mediated signaling pathway
- intracellular receptor signaling pathway
- cell population proliferation
- leptin-mediated signaling pathway
- interleukin-15-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- interleukin-9-mediated signaling pathway
- interleukin-11-mediated signaling pathway
- interleukin-23-mediated signaling pathway
- interleukin-6-mediated signaling pathway
- interleukin-10-mediated signaling pathway
- intracellular receptor signaling pathway
- regulation of cell cycle
- regulation of multicellular organism growth
biological process
metabolic process [inference]
cellular process [inference]
signal transduction
cell surface receptor signaling pathway [inference]
cytokine-mediated signaling pathway
cellular metabolic process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of transcription, DNA-templated
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of transcription, DNA-templated
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of transcription, DNA-templated
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction
cell surface receptor signaling pathway [inference]
cytokine-mediated signaling pathway
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of transcription, DNA-templated
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| transcription regulator complex | ||
| chromatin | ||
| cytoplasm | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling adaptor activity | ||
| DNA binding | ||
| protein kinase binding | ||
| transcription cis-regulatory region binding | ||
| protein dimerization activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Signal transducer and activator of transcription
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine-mediated signaling pathway |
| receptor signaling pathway via JAK-STAT |
| regulation of cell population proliferation |
| response to peptide hormone |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0001816 | angiosarcoma | |
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0060704 | lymphoproliferative syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0080797 | nasal type extranodal NK/T-cell lymphoma | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20848 | MGI:103038 | MOUSE04112 | ||
| 25125 | RGD:3772 | RATNO03313 | ||
| 30767 | ZFIN:ZDB-GENE-980526-68 | DANRE31102 | ||
| 42428 | FB:FBgn0016917 | |||
| 178465 | WB:WBGene00013111 | |||
| 454682 | 9598_0:00442a | PANTR13875 | ||
| 490967 | CANLF18699 | |||
| 508541 | BOVIN13380 | |||
| 574128 | MACMU15607 | |||
| 733648 | PIGXX02264 |
