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NPC intracellular cholesterol transporter 2

Summary

Gene Symbol

Npc2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67963

PubChem

67963

Alliance of Genome Resources

MGI:1915213

Annotation

Keyword

Acetylation
Cholesterol metabolism
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z0J0	Epididymal secretory protein E1 Niemann Pick type C2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IEA
cholesterol transport	IMP ISO ISS	17018531 21315718
cholesterol efflux	IBA IMP ISO	21315718
intracellular sterol transport	ISO ISS	17018531
response to virus	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process

cholesterol metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport

intracellular cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport

intracellular cholesterol transport

organic substance transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport

intracellular sterol transport

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport

intracellular cholesterol transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

intracellular sterol transport

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport

intracellular cholesterol transport

maintenance of location [inference]

lipid storage [inference]

cholesterol storage

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport

intracellular cholesterol transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
lysosome	IDA ISO ISS	11125141 21289032 29514215
endoplasmic reticulum	IEA
extracellular space	HDA ISO	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cholesterol transfer activity	IEA ISO
enzyme binding	IEA ISO
cholesterol binding	IBA IMP ISO ISS	17018531 21315718

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

protein binding [inference]

enzyme binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

NPC intracellular cholesterol transporter 2

Functional Category

K: Transcription
L: Replication, recombination and repair
N: Cell motility
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cholesterol binding
cholesterol efflux
intracellular cholesterol transport
sterol transport

Displaying **all 4** entries
InterPro
Immunoglobulin E-set
MD-2-related lipid-recognition domain
Npc2 like, ML domain
Sterol transport protein NPC2-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070114	Niemann-Pick disease type C2	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10577		HGNC:14537	HUMAN20282
Drosophila melanogaster	33374		FB:FBgn0031381
Drosophila melanogaster	41710		FB:FBgn0038198
Caenorhabditis elegans	175426		WB:WBGene00006452
Bos taurus	280815			BOVIN01723
Danio rerio	282673		ZFIN:ZDB-GENE-021206-13	DANRE12308
Rattus norvegicus	286898	10116_1:00255f	RGD:628756	RATNO35263
Sus scrofa	397410			PIGXX32827
Canis lupus familiaris	403920			CANLF18082
Xenopus tropicalis	493351		Xenbase:XB-GENE-6258064

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements