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syntaxin 1A

Summary

Gene Symbol

STX1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

6804

PubChem

6804

Alliance of Genome Resources

HGNC:11433

Annotation

Keyword

Alternative splicing
Cell membrane
Coiled coil
Cytoplasmic vesicle
Exocytosis
Isopeptide bond
Neurotransmitter transport
Phosphoprotein
Reference proteome
Secreted
Synaptosome
Transmembrane helix
Ubl conjugation
Williams-Beuren syndrome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q16623	Neuron-specific antigen HPC-1
Q75ME0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
positive regulation of excitatory postsynaptic potential	IEA
positive regulation of catecholamine secretion	ISS
positive regulation of calcium ion-dependent exocytosis	ISS
positive regulation of neurotransmitter secretion	IEA
secretion by cell	IDA	12130530

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis

regulated exocytosis [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

membrane organization [inference]

synaptic vesicle membrane organization [inference]

synaptic vesicle fusion to presynaptic active zone membrane

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

exocytic process [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

export from cell [inference]

secretion by cell

exocytosis

regulated exocytosis [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

vesicle-mediated transport [inference]

exocytosis

regulated exocytosis [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell

exocytosis

regulated exocytosis [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

export from cell [inference]

secretion by cell

exocytosis

regulated exocytosis [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization in cell [inference]

synaptic vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of protein secretion [inference]

regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of protein secretion [inference]

regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
voltage-gated potassium channel complex	ISS
synaptic vesicle membrane	IEA
nuclear membrane	IEA
plasma membrane	IBA IDA TAS	10099709 12730201 17543282 24885604
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

SNARE complex

synaptobrevin 2-SNAP-25-syntaxin-1a complex

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

nuclear membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
kinase binding	IPI	12730201
protein binding	IPI	10321247 10481273 12730201 15459722 16169070 19748891 20798282 24722188 26635000 30610939 32296183
calcium channel inhibitor activity	IEA
chloride channel inhibitor activity	IDA	18570918
SNAP receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding

enzyme binding [inference]

kinase binding

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

SNAP receptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

chloride channel regulator activity [inference]

chloride channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SYNTAXIN

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SNARE binding
vesicle docking

Displaying **all 4** entries
InterPro
SNARE
Syntaxin, N-terminal domain
Syntaxin
Target SNARE coiled-coil homology domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10487	Hirschsprung's disease	Alliance of Genome Resources
DOID:11949	Creutzfeldt-Jakob disease	Alliance of Genome Resources
DOID:150	disease of mental health	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20907		MGI:109355	MOUSE46565
Drosophila melanogaster	42854		FB:FBgn0013343
Rattus norvegicus	116470		RGD:69430	RATNO05194
Caenorhabditis elegans	176743		WB:WBGene00006798
Macaca mulatta	574205			MACMU31570
Pan troglodytes	742605	9598_0:0020b9		PANTR40506
Xenopus tropicalis	779637		Xenbase:XB-GENE-976753
Bos taurus	788566			BOVIN20750
Saccharomyces cerevisiae S288C	855221		SGD:S000004795
Saccharomyces cerevisiae S288C	855844		SGD:S000006153

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements