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MIRAGE
ATP binding cassette subfamily C member 8
Summary
- Gene Symbol
-
- ABCC8
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Diabetes mellitus
- Disease variant
- Glycoprotein
- Receptor
- Reference proteome
- Repeat
- Transmembrane helix
- Transport
- Proteins
| UniProt | Protein Name |
|---|---|
| Q09428 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| action potential | ||
| intracellular glucose homeostasis | ||
| potassium ion transport | ||
| female pregnancy | ||
| memory |
GO Hierarchy
biological process
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of cellular localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular localization [inference]
regulation of secretion by cell [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| inward rectifying potassium channel | ||
| inward rectifying potassium channel | ||
| membrane | ||
| synaptic vesicle membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| potassium channel activity | ||
| protein binding | ||
| ATP binding | ||
| sulfonylurea receptor activity | ||
| ATP-activated inward rectifier potassium channel activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- ABC
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ABC-type transporter activity |
| ATP binding |
| nucleotide binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060639 | permanent neonatal diabetes mellitus | |
| DOID:0070219 | familial hyperinsulinemic hypoglycemia 1 | |
| DOID:0112262 | leucine-sensitive hypoglycemia of infancy | |
| DOID:10763 | hypertension | |
| DOID:2018 | hyperinsulinism | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6833 | ZFIN:ZDB-GENE-050517-22 | ||
| 10060 | SGD:S000003971 | ||
| 20927 | ZFIN:ZDB-GENE-050517-22 | MOUSE55542 | |
| 20928 | FB:FBgn0028675 | ||
| 25559 | ZFIN:ZDB-GENE-120215-45 | RATNO16937 | |
| 25560 | FB:FBgn0028675 | ||
| 89845 | SGD:S000003971 | ||
| 451056 | PANTR02399 | ||
| 485402 | CANLF08576 | ||
| 538996 | BOVIN06676 |
