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Guidelines

MIRAGE

glucose 6 phosphatase, catalytic, 3

Summary

Gene Symbol

G6pc3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68401

PubChem

68401

Alliance of Genome Resources

MGI:1915651

Annotation

Keyword

Endoplasmic reticulum
Gluconeogenesis
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6NSQ9	Ubiquitous glucose-6-phosphatase catalytic subunit-related protein glucose-6-phosphatase-beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
gluconeogenesis	ISO
gluconeogenesis	IDA	15661744
gluconeogenesis	IBA
gluconeogenesis	IEA
glucose-6-phosphate transport	IGI	15661744

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum	IDA	10787428 15661744
endoplasmic reticulum membrane	IEA
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glucose-6-phosphatase activity	ISA	15661744
glucose-6-phosphatase activity	ISO
glucose-6-phosphatase activity	IDA	15661744
glucose-6-phosphatase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

sugar-terminal-phosphatase activity [inference]

glucose-6-phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glucose-6-phosphatase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
gluconeogenesis
glucose-6-phosphatase activity
hydrolase activity

Displaying **all 3** entries
InterPro
Glucose-6-phosphatase
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

Rhea

H₂O + α-D-glucose 6-phosphate

α-D-glucose + phosphate

Enzyme

H₂O + D-glucose 6-phosphate

D-glucose + phosphate

Enzyme

PMID

Ortholog

Displaying entries **31 - 40** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Felis catus	101097770		FELCA30949
Gorilla gorilla gorilla	101128335		GORGO32403
Oryzias latipes	101162637		ORYLA08194
Tursiops truncatus	101327107		TURTR13454
Jaculus jaculus	101617406		JACJA06741
Mustela putorius furo	101686925		MUSPF04780
Heterocephalus glaber	101723886		HETGA22870
Chrysemys picta bellii	101952165		CHRPI09184
Ictidomys tridecemlineatus	101971812		ICTTR02923
Macaca fascicularis	102139699		MACFA14339

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 7, 2025