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synapsin II

Summary

Gene Symbol

SYN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6854

PubChem

6854

Alliance of Genome Resources

HGNC:11495

Annotation

Keyword

Alternative splicing
Phosphoprotein
Reference proteome
Schizophrenia
Synapse

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q86VA8
Q59GM1
Q92777	Synapsin II
B3KRB3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
synaptic vesicle clustering	IBA IEA
synapse organization	IBA
neurotransmitter secretion	ISS
calcium-ion regulated exocytosis	IEA
chemical synaptic transmission	TAS	8964517

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

neurotransmitter secretion

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IBA ISS
Schaffer collateral - CA1 synapse	IEA
postsynaptic density	IEA
plasma membrane	IEA
synapse	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

SNARE complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

cell junction [inference]

synapse

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23406870
identical protein binding	IEA
ATP binding	TAS	15217342

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Synapsin

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 4** entries
InterPro
Pre-ATP-grasp domain superfamily
Synapsin, ATP-binding domain
Synapsin, pre-ATP-grasp domain
Synapsin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20965		MGI:103020
Rattus norvegicus	29179		RGD:3798
Drosophila melanogaster	41247		FB:FBgn0004575
Caenorhabditis elegans	176987		WB:WBGene00004913
Xenopus laevis	373810		Xenbase:XB-GENE-6252419
Danio rerio	436870		ZFIN:ZDB-GENE-040718-341	DANRE23986
Danio rerio	641578		ZFIN:ZDB-GENE-051127-49
Macaca mulatta	695412			MACMU29752
Xenopus laevis	734421		Xenbase:XB-GENE-959240
Pan troglodytes	749839	9598_0:00111e		PANTR30450

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements