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synaptophysin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

6855

PubChem

6855

Alliance of Genome Resources

HGNC:11506

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasmic vesicle
Disease variant
Glycoprotein
Intellectual disability
Phosphoprotein
Reference proteome
Repeat
Synaptosome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P08247	Major synaptic vesicle protein p38

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of long-term neuronal synaptic plasticity	ISS
endocytosis	ISS
synaptic vesicle maturation	NAS	10620806
synaptic vesicle membrane organization	NAS	10620806
regulation of short-term neuronal synaptic plasticity	ISS

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

synaptic vesicle maturation

membrane organization [inference]

synaptic vesicle membrane organization

developmental process [inference]

developmental maturation [inference]

synaptic vesicle maturation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IBA NAS	1975480
Schaffer collateral - CA1 synapse	IEA
terminal bouton	IEA
neuromuscular junction	IEA
neuron projection	IDA ISS	8838578

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

presynapse [inference]

terminal bouton

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17500595 32296183 32814053
identical protein binding	IEA
cholesterol binding	IDA	10620806
SH2 domain binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

SH2 domain binding

identical protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Synaptophysin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Marvel domain
Synaptophysin/synaptoporin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0112035	non-syndromic X-linked intellectual disability 96	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20977		MGI:98467	MOUSE65555
Rattus norvegicus	24804		RGD:3802
Caenorhabditis elegans	177608		WB:WBGene00004979
Bos taurus	280937			BOVIN37060
Xenopus laevis	394284		Xenbase:XB-GENE-943865
Xenopus laevis	394285		Xenbase:XB-GENE-6254665
Danio rerio	436774		ZFIN:ZDB-GENE-040718-205
Pan troglodytes	465628	9598_0:00556e		PANTR45989
Danio rerio	559698		ZFIN:ZDB-GENE-031104-2	DANRE43459
Canis lupus familiaris	612557			CANLF19772