ADAM metallopeptidase domain 17

Summary
Gene Symbol
  • ADAM17
Organism
Homo sapiens (human)
NCBI Gene
6868
PubChem
6868
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Metalloprotease
  • Notch signaling pathway
  • Phosphoprotein
  • Reference proteome
  • SH3-binding
  • Signal
  • Transmembrane helix
  • Zinc
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
B2RNB2
P78536
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
Gene Ontology (GO)
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
ADAM 17
Functional Category
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Disease
Disease Ontology
Displaying all 7 entries
DO ID Disease Name Source
DOID:0050589 inflammatory bowel disease
DOID:0050855 renal fibrosis
DOID:10652 Alzheimer's disease
DOID:14004 thoracic aortic aneurysm
DOID:3310 atopic dermatitis
DOID:6000 congestive heart failure
DOID:9352 type 2 diabetes mellitus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024