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transporter 1, ATP binding cassette subfamily B member

Summary

Gene Symbol

TAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6890

PubChem

6890

Alliance of Genome Resources

HGNC:43

Annotation

Keyword

3D-structure
ATP-binding
Adaptive immunity
Alternative initiation
Endoplasmic reticulum
Host-virus interaction
Magnesium
Metal-binding
Peptide transport
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B7Z7P4
Q03518	ATP-binding cassette sub-family B member 2 Peptide supply factor 1 Peptide transporter PSF1 Peptide transporter TAP1 Peptide transporter involved in antigen processing 1 Really interesting new gene 4 protein
A0A0S2Z5A6
X5CKB3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
defense response	IEA
protein transport	IEA
peptide transport	IMP	11133832 17418234
antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA	11133832

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

transmembrane transport

cytosol to endoplasmic reticulum transport

response to stimulus [inference]

response to stress [inference]

defense response

immune response [inference]

adaptive immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

transmembrane transport

cytosol to endoplasmic reticulum transport

organic substance transport [inference]

nitrogen compound transport [inference]

protein transport

amide transport [inference]

peptide transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	11133832 15577206 22638925 7673167
membrane	IDA	8955196
membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

centriolar satellite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **16 - 19** of 19 in total

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GO Term	Evidence Code	PMID
TAP1 binding	ISS
TAP1 binding	IBA
TAP2 binding	IPI	11133832 1538751 15518576
peptide transmembrane transporter activity	IMP	17418234

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

amide transmembrane transporter activity [inference]

peptide transmembrane transporter activity

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

TAP binding [inference]

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

peptide antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0060009	MHC class I deficiency	Alliance of Genome Resources
DOID:1067	open-angle glaucoma	Alliance of Genome Resources
DOID:1205	allergic disease	Alliance of Genome Resources
DOID:1580	diffuse scleroderma	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:4483	rhinitis	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:6196	reactive arthritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6890	Xenbase:XB-GENE-486762
Mus musculus	21354		MOUSE20135
Caenorhabditis elegans	23457	WB:WBGene00001814
Rattus norvegicus	24811		RATNO22094
Pan troglodytes	471978		PANTR37860
Canis lupus familiaris	474866		CANLF02611
Bos taurus	524959		BOVIN18257
Macaca mulatta	717726		MACMU34722
Sus scrofa	733649		PIGXX31288
Monodelphis domestica	100026750		MONDO12669

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Annotation

OrthoDB (Group)

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Acknowledgements