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Guidelines
MIRAGE
transforming growth factor beta 1
Summary
- Gene Symbol
-
- TGFB1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Growth factor
- Mitogen
- Proteomics identification
- Reference proteome
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A499FJK2 |
|
| P01137 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| cell morphogenesis | ||
| vasculogenesis | ||
| ureteric bud development | ||
| response to hypoxia |
|
GO Hierarchy
- response to xenobiotic stimulus
- response to salt
- positive regulation of cell division
- positive regulation of cell division
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
cellular developmental process [inference]
cellular response to stimulus [inference]
multicellular organismal process [inference]
developmental process [inference]
homeostatic process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
response to organic substance [inference]
cellular response to chemical stimulus [inference]
response to oxygen-containing compound [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
negative regulation of immune effector process [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
negative regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of cellular localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
negative regulation of developmental process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
negative regulation of immune response [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
negative regulation of developmental process [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell killing [inference]
regulation of transmembrane transport [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of cellular localization [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of epithelial cell migration [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| extracellular space | ||
| nucleus |
| GO Term | Evidence Code | PMID |
|---|---|---|
| type II transforming growth factor beta receptor binding | ||
| type II transforming growth factor beta receptor binding | ||
| type II transforming growth factor beta receptor binding | ||
| cytokine activity | ||
| cytokine activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Transforming growth factor beta-1
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:10322 | berylliosis | |
| DOID:12134 | factor VIII deficiency | |
| DOID:12449 | aplastic anemia | |
| DOID:13141 | uveitis | |
| DOID:13241 | Behcet's disease | |
| DOID:13406 | pulmonary sarcoidosis | |
| DOID:13922 | eosinophilic esophagitis | |
| DOID:1485 | cystic fibrosis | |
| DOID:1612 | breast cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 7040 | Xenbase:XB-GENE-488111 | ||
| 16323 | FB:FBgn0031461 | ||
| 16324 | FB:FBgn0031461 | ||
| 16325 | FB:FBgn0031461 | ||
| 16326 | FB:FBgn0031461 | ||
| 21803 | Xenbase:XB-GENE-488111 | MOUSE51399 | |
| 59086 | Xenbase:XB-GENE-488111 | RATNO17590 | |
| 64549 | FB:FBgn0031461 | ||
| 83711 | FB:FBgn0031461 | ||
| 282089 | BOVIN11147 |
