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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
thrombomodulin
Summary
- Gene Symbol
-
- THBD
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Hemolytic uremic syndrome
- Hydroxylation
- Proteoglycan
- Receptor
- Reference proteome
- Repeat
- Signal
- Thrombophilia
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P07204 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| negative regulation of fibrinolysis | ||
| negative regulation of blood coagulation | ||
| response to X-ray | ||
| response to cAMP |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| apicolateral plasma membrane | ||
| plasma membrane | ||
| cell surface | ||
| serine-type endopeptidase complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| signaling receptor activity | ||
| calcium ion binding | ||
| transmembrane signaling receptor activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Kinase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:0111908 | thrombophilia due to thrombomodulin defect | |
| DOID:0112313 | brain small vessel disease | |
| DOID:10223 | dermatomyositis | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:11394 | adult respiratory distress syndrome | |
| DOID:12132 | granulomatosis with polyangiitis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21824 | MGI:98736 | MOUSE35899 | ||
| 42820 | FB:FBgn0085384 | |||
| 47137 | FB:FBgn0001321 | |||
| 83580 | RGD:621299 | RATNO26151 | ||
| 180836 | WB:WBGene00020921 | |||
| 469898 | 9598_0:00508d | PANTR24490 | ||
| 474355 | CANLF09242 | |||
| 702132 | MACMU01602 | |||
| 100049012 | FELCA08106 | |||
| 100078930 | ORNAN11578 |
