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mutY DNA glycosylase

Summary

Gene Symbol

Mutyh

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

70603

PubChem

70603

Alliance of Genome Resources

MGI:1917853

Annotation

Keyword

3D-structure
4Fe-4S
DNA repair
Glycosidase
Mitochondrion
Nucleus
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q762D1
Q99P21	MutY homolog
Q762C9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
base-excision repair	IBA IEA
DNA repair	TAS	12200441
mismatch repair	IBA
negative regulation of necroptotic process	IMP	28059467
response to oxidative stress	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleoplasm	ISO TAS
mitochondrion	HDA	18614015
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA
DNA binding	IEA
oxidized purine DNA binding	IBA
adenine/guanine mispair binding	IBA
MutSalpha complex binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

mismatch repair complex binding [inference]

MutSalpha complex binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding [inference]

oxidized DNA binding [inference]

oxidized purine DNA binding

double-stranded DNA binding [inference]

mismatched DNA binding [inference]

adenine/guanine mispair binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

DNA glycosylase

Functional Category

F: Nucleotide transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
4 iron, 4 sulfur cluster binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
adenine/guanine mispair binding
base-excision repair
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
iron-sulfur cluster binding
metal ion binding

Displaying **all 9** entries
InterPro
Adenine DNA glycosylase, C-terminal
Adenine/Thymine-DNA glycosylase
DNA glycosylase
Endonuclease III-like, conserved site-2
Endonuclease III-like, iron-sulphur cluster loop motif
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain
NUDIX hydrolase domain
NUDIX hydrolase-like domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050424	familial adenomatous polyposis	Alliance of Genome Resources
DOID:0080410	familial adenomatous polyposis 2	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **101** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Felis catus	101089880		FELCA21167
Ovis aries	101119344		SHEEP00254
Gorilla gorilla gorilla	101149779		GORGO21092
Octodon degus	101560370	10160_0:0031f0
Jaculus jaculus	101613498	51337_0:001c2e	JACJA22577
Mustela putorius furo	101689944		MUSPF18175
Heterocephalus glaber	101706875	10181_0:0049ed
Mesocricetus auratus	101836609	10036_0:00302d
Ictidomys tridecemlineatus	101968388	43179_0:001c4d	ICTTR09141
Microtus ochrogaster	102002911	79684_0:004781