GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Dwarfism
Isopeptide bond
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Thiamine pyrophosphate
Transferase
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P29401
V9HWD9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
pentose-phosphate shunt, non-oxidative branch	IBA NAS	9357955
xylulose 5-phosphate biosynthetic process	IEA
pentose-phosphate shunt	IDA	20667822
glyceraldehyde-3-phosphate biosynthetic process	IDA	9611778
regulation of growth	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

biosynthetic process [inference]

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organic substance biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pentose-phosphate shunt, non-oxidative branch

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

organic substance biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pentose-phosphate shunt, non-oxidative branch

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

biological regulation [inference]

regulation of biological process [inference]

regulation of growth

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nuclear body	IDA
vesicle	HDA	19190083
cytosol
endoplasmic reticulum membrane	IBA
peroxisome	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA	9611778
protein homodimerization activity	IDA	20667822 9357955
thiamine pyrophosphate binding	IBA
transketolase activity	IBA IDA	20667822 8419340 9357955 9611778
calcium ion binding	IDA	20667822

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transketolase or transaldolase activity [inference]

transketolase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

thiamine pyrophosphate binding

quaternary ammonium group binding [inference]

thiamine pyrophosphate binding

heterocyclic compound binding [inference]

thiamine pyrophosphate binding

ion binding [inference]

anion binding [inference]

thiamine pyrophosphate binding

cation binding [inference]

thiamine pyrophosphate binding

metal ion binding [inference]

organic cyclic compound binding [inference]

thiamine pyrophosphate binding

sulfur compound binding [inference]

thiamine pyrophosphate binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000163931

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00615

Name

transketolase [EC:2.2.1.1]

References

8419340

Rhea

RHEA:10508

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

D-xylulose 5-phosphate + aldehydo-D-ribose 5-phosphate

Enzyme

2.2.1.1

PMID

RHEA:27626

D-erythrose 4-phosphate + D-xylulose 5-phosphate

β-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate

Enzyme

2.2.1.1

Disease

Disease Ontology

Displaying entries **1 - 10** of **144** in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050741	alcohol dependence	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0110752	type 1 diabetes mellitus 13	DisGeNET
DOID:0070313	thiamine deficiency disease	DisGeNET DisGeNET
DOID:0070318	dry beriberi	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 30 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000107	Renal cyst
HP:0000365	Hearing impairment
HP:0000486	Strabismus
HP:0000509	Conjunctivitis
HP:0000518	Cataract
HP:0000519	Developmental cataract
HP:0000554	Uveitis
HP:0000722	Compulsive behaviors
HP:0000733	Motor stereotypy

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:488618	transketolase deficiency
OMIM:617044	transketolase deficiency

PubChem Disease

MedGen Diseases

Transketolase deficiency

OMIM Phenotypes

SHORT STATURE, DEVELOPMENTAL DELAY, AND CONGENITAL HEART DEFECTS; SDDHD

KEGG Diseases

Short stature, developmental delay, congenital heart defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177906	WB:WBGene00008506
Drosophila melanogaster	40012	FB:FBgn0036784
Drosophila melanogaster	41027	FB:FBgn0037607
Callorhinchus milii	103185044		CALMI31270
Latimeria chalumnae	102356292		LATCH15672
Danio rerio	378713	ZFIN:ZDB-GENE-030909-13
Danio rerio	557518	ZFIN:ZDB-GENE-130530-578
Astyanax mexicanus	103045188		ASTMX02108
Ictalurus punctatus	108265455		ICTPU29544
Esox lucius	105026343		ESOLU36058

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements