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angiotensin converting enzyme 2

Summary

Gene Symbol

ACE2

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 712790
PubChem: 712790

Annotation

Keyword

Carboxypeptidase
Cell membrane
Cell projection
Chloride
Cytoplasm
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F7AH40
B6DUG6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of gap junction assembly
proteolysis	IEA	22301074 30032202
regulation of cardiac conduction
tryptophan transport
positive regulation of L-proline import across plasma membrane

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

drinking behavior [inference]

angiotensin-mediated drinking behavior

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell [inference]

receptor-mediated virion attachment to host cell [inference]

entry receptor-mediated virion attachment to host cell

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

nitrogen compound transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac conduction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
apical plasma membrane
plasma membrane	IEA	30032202
extracellular region
cell surface
brush border membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
peptidyl-dipeptidase activity	IEA	22301074 30032202
metal ion binding
identical protein binding
endopeptidase activity
metallopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

exopeptidase activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	59272	HUMAN99860
Mus musculus	70008	MOUSE66145
Rattus norvegicus	302668	RATNO45031
Pan troglodytes	465511	PANTR45543
Canis lupus familiaris	480847	CANLF19581
Danio rerio	492331	DANRE02620
Bos taurus	509235	BOVIN37428
Felis catus	554349	FELCA39694
Monodelphis domestica	100031783	MONDO31397
Equus caballus	100055952	HORSE44018

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements