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tenascin XB

Summary

Gene Symbol

TNXB

Organism

Homo sapiens (human)

External Links

NCBI Gene

7148

PubChem

7148

Alliance of Genome Resources

HGNC:11976

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Coiled coil
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Ehlers-Danlos syndrome
Extracellular matrix
Glycoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
O95680
O95681
P22105	Hexabrachion-like protein
Q9Y464
Q6IPK3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
collagen fibril organization	IEA
regulation of cell differentiation	NAS	25793578
neuron projection development	IBA
positive regulation of cell fate determination	NAS	25793578
fatty acid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

collagen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

positive regulation of cell fate determination

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell fate determination

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell fate determination

regulation of cell fate determination [inference]

positive regulation of cell fate determination

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

positive regulation of cell fate determination

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization [inference]

positive regulation of collagen fibril organization

regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization [inference]

positive regulation of collagen fibril organization

regulation of cell fate determination [inference]

positive regulation of cell fate determination

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular matrix	NAS	7686164
collagen-containing extracellular matrix	HDA IBA ISS NAS	20551380 22261194 25037231 25793578 27559042 28327460 28675934
tenascin complex	ISO
intracellular membrane-bounded organelle	IDA
extracellular region	HDA	27068509

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion [inference]

tenascin complex

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21516116 25416956 32296183 32814053 35443807
integrin binding	ISS
heparin binding	ISS
extracellular matrix structural constituent	ISS RCA	20551380 25037231 27559042 28327460 28675934
collagen fibril binding	IDA	16278880

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

collagen fibril binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tenascin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
EGF-like domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:9620	vesicoureteral reflux	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 17 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	81877		MGI:1932137
Caenorhabditis elegans	174432		WB:WBGene00007687
Caenorhabditis elegans	175384		WB:WBGene00002915
Rattus norvegicus	415089		RGD:1594402
Pan troglodytes	462578	9598_0:001f85		PANTR37798
Pongo abelii	100443502	9601_0:001bd6
Xenopus tropicalis	100489649		Xenbase:XB-GENE-481849
Danio rerio	100536295		ZFIN:ZDB-GENE-070103-5
Nomascus leucogenys	100597679			NOMLE18447
Pan paniscus	100992963	9597_0:001cda

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements