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DNA topoisomerase II alpha
Summary
- Gene Symbol
-
- TOP2A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Biological rhythms
- Cytoplasm
- DNA-binding
- Direct protein sequencing
- Isopeptide bond
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Topoisomerase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P11388 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| resolution of meiotic recombination intermediates | ||
| positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | ||
| sister chromatid segregation | ||
| hematopoietic progenitor cell differentiation | ||
| regulation of circadian rhythm |
GO Hierarchy
- rhythmic process
- regulation of circadian rhythm
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
regulation of viral process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | ||
| condensed chromosome | ||
| protein-containing complex | ||
| ribonucleoprotein complex | ||
| nuclear chromosome |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | ||
| DNA binding | ||
| chromatin binding | ||
| protein heterodimerization activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- topoisomerase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| DNA topological change |
| isomerase activity |
| metal ion binding |
| nucleotide binding |
| resolution of meiotic recombination intermediates |
| sister chromatid segregation |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060074 | ductal carcinoma in situ | |
| DOID:10283 | prostate cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11624 | penile benign neoplasm | |
| DOID:162 | cancer | |
| DOID:2115 | B cell deficiency | |
| DOID:2154 | nephroblastoma | |
| DOID:8991 | cervix uteri carcinoma in situ | |
| DOID:9119 | acute myeloid leukemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21973 | MGI:98790 | MOUSE03590 | ||
| 35225 | FB:FBgn0284220 | |||
| 174825 | WB:WBGene00010785 | |||
| 323733 | ZFIN:ZDB-GENE-030131-2453 | |||
| 360243 | RGD:62048 | RATNO01661 | ||
| 396917 | PIGXX02395 | |||
| 398512 | Xenbase:XB-GENE-970184 | |||
| 454651 | 9598_0:0047dd | PANTR14014 | ||
| 480525 | CANLF18768 | |||
| 700707 | MACMU13815 |
