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DNA topoisomerase II beta
Summary
- Gene Symbol
-
- TOP2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Autism spectrum disorder
- DNA-binding
- Disease variant
- Isomerase
- Isopeptide bond
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Topoisomerase
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cellular senescence | ||
| resolution of meiotic recombination intermediates | ||
| positive regulation of double-strand break repair via nonhomologous end joining | ||
| positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | ||
| neuron migration |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of viral process [inference]
regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | ||
| DNA binding | ||
| chromatin binding | ||
| metal ion binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- topoisomerase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| DNA topological change |
| isomerase activity |
| metal ion binding |
| nucleotide binding |
| resolution of meiotic recombination intermediates |
| sister chromatid segregation |
Disease
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21974 | MGI:98791 | MOUSE14768 | ||
| 35225 | FB:FBgn0284220 | |||
| 174825 | WB:WBGene00010785 | |||
| 191525 | WB:WBGene00022854 | |||
| 282097 | BOVIN22207 | |||
| 361100 | RGD:1586156 | RATNO09474 | ||
| 460232 | 9598_0:00124f | PANTR30622 | ||
| 477044 | CANLF09028 | |||
| 569877 | ZFIN:ZDB-GENE-041008-136 | DANRE14867 | ||
| 677709 | MACMU30183 |
