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DNA topoisomerase III alpha

Summary

Gene Symbol

TOP3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

7156

PubChem

7156

Alliance of Genome Resources

HGNC:11992

Annotation

Keyword

3D-structure
Alternative splicing
DNA-binding
Disease variant
Dwarfism
Magnesium
Mitochondrion
Progressive external ophthalmoplegia
Reference proteome
Repeat
Topoisomerase
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13472	DNA topoisomerase III alpha

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	IDA	23543748
DNA topological change	IDA	20445207
DNA topological change	IBA
DNA repair	IBA
DNA recombination	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

cell cycle process [inference]

chromosome separation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA topological change

reproductive process [inference]

meiotic cell cycle

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	23543748
nucleus	IBA
nucleoplasm	TAS
mitochondrion	HTP	34800366
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

RecQ family helicase-topoisomerase III complex

cellular anatomical entity [inference]

nucleoplasm

nuclear body [inference]

PML body

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	TAS	8622991
single-stranded DNA binding	IDA	29290614
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	20445207
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA
protein binding	IPI	10728666 15775963 16537486 20360068 20711169 20826342 23509288 24509834 26496610 33961781 35271311

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

single-stranded DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna topoisomerase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
DNA topoisomerase type I (single strand cut, ATP-independent) activity
DNA topological change
isomerase activity

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InterPro
DNA topoisomerase 3-like, TOPRIM domain
DNA topoisomerase, type IA, DNA-binding domain
DNA topoisomerase, type IA, active site
DNA topoisomerase, type IA, central region, subdomain 1
DNA topoisomerase, type IA, central region, subdomain 2
DNA topoisomerase, type IA, central region, subdomain 3
DNA topoisomerase, type IA, central
DNA topoisomerase, type IA, core domain
DNA topoisomerase, type IA, domain 2
DNA topoisomerase, type IA

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111524	autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7156	Xenbase:XB-GENE-1003600
Mus musculus	21975		MOUSE04041
Rattus norvegicus	303194		RATNO01530
Pan troglodytes	454488		PANTR14652
Canis lupus familiaris	489537		CANLF15581
Bos taurus	527411		BOVIN12959
Danio rerio	560212		DANRE31265
Macaca mulatta	700830		MACMU14312
Monodelphis domestica	100029388		MONDO30814
Ornithorhynchus anatinus	100079154		ORNAN16665