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tumor protein p53 binding protein 2

Summary

Gene Symbol

TP53BP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7159

PubChem

7159

Alliance of Genome Resources

HGNC:12000

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Apoptosis
Cell cycle
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH3 domain
SH3-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13625	Bcl2-binding protein Renal carcinoma antigen NY-REN-51 Tumor suppressor p53-binding protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11684014
negative regulation of cell cycle	TAS	14729977
positive regulation of execution phase of apoptosis	IMP	14985081
signal transduction	TAS	9748285

GO Hierarchy

biological process

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell cycle

regulation of cell cycle [inference]

negative regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA TAS	10646860 14985081 15782125 19377511

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10498867 10646860 11278422 11684014 12694406 14729977 14985081 15161933 15231748 17965023 18275817 18448430 18719108 19377511 21513714 21988832 21998301 22321011 24366813 24855949 25344754 25416956 25436413 25502805 25963096 26496610 28330616 28514442 31515488 33961781 36931259 8875926
NF-kappaB binding	IPI	10498867
SH3 domain binding	IEA
identical protein binding	IPI	18448430
p53 binding	IBA IPI	14985081

GO Hierarchy

molecular function

binding [inference]

protein binding

p53 binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

NF-kappaB binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apoptosis-stimulating of p53 protein

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
p53 binding
regulation of apoptotic process

Displaying **all 5** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Apoptosis-stimulating of p53 protein 1/2
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060412	chromosome 1q41-q42 deletion syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37422		FB:FBgn0034606
Caenorhabditis elegans	179601		WB:WBGene00000146
Mus musculus	209456		MGI:2138319	MOUSE28163
Rattus norvegicus	305025		RGD:1305461	RATNO06432
Danio rerio	407983		ZFIN:ZDB-GENE-040516-8	DANRE05123
Xenopus laevis	414498		Xenbase:XB-GENE-17340972
Xenopus laevis	446947		Xenbase:XB-GENE-962020
Pan troglodytes	457766	9598_0:000169		PANTR23771
Canis lupus familiaris	490397			CANLF17359
Bos taurus	514474			BOVIN08064

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OrthoDB (Group)

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Acknowledgements