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tumor protein p53 binding protein 2

Summary

Gene Symbol

TP53BP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7159

PubChem

7159

Alliance of Genome Resources

HGNC:12000

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Apoptosis
Cell cycle
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH3 domain
SH3-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13625	Bcl2-binding protein Renal carcinoma antigen NY-REN-51 Tumor suppressor p53-binding protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11684014
negative regulation of cell cycle	TAS	14729977
positive regulation of execution phase of apoptosis	IMP	14985081
signal transduction	TAS	9748285

GO Hierarchy

biological process

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell cycle

regulation of cell cycle [inference]

negative regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA TAS	10646860 14985081 15782125 19377511

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
protein homodimerization activity	IPI	25963096

GO Hierarchy

molecular function

binding [inference]

protein binding

p53 binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

NF-kappaB binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apoptosis-stimulating of p53 protein

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
p53 binding
regulation of apoptotic process

Displaying **all 5** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Apoptosis-stimulating of p53 protein 1/2
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060412	chromosome 1q41-q42 deletion syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 88 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pan paniscus	100989224	9597_0:000452	PANPA03848
Papio anubis	101023677		PAPAN19040
Saimiri boliviensis boliviensis	101035278		SAIBB17222
Takifugu rubripes	101075443		TAKRU39168
Felis catus	101083477		FELCA36743
Ovis aries	101108587		SHEEP03601
Gorilla gorilla gorilla	101147536	9595_0:0000c3	GORGO21474
Oryzias latipes	101156674		ORYLA05012
Tursiops truncatus	101320502		TURTR04593
Octodon degus	101568905		OCTDE04631

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements