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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
complement C4A (Chido/Rodgers blood group)
Summary
- Gene Symbol
-
- C4A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Blood group antigen
- Cell projection
- Cleavage on pair of basic residues
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Inflammatory response
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Sulfation
- Synapse
- Systemic lupus erythematosus
- Thioester bond
- Proteins
| UniProt | Protein Name |
|---|---|
| P0C0L4 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| innate immune response | ||
| complement activation, classical pathway | ||
| positive regulation of apoptotic cell clearance | ||
| inflammatory response | ||
| complement activation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuronal cell body | ||
| endoplasmic reticulum lumen | ||
| plasma membrane | ||
| extracellular region | ||
| dendrite |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| endopeptidase inhibitor activity | ||
| complement component C1q complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- C3
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- P: Inorganic ion transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
| Gene Ontology |
|---|
| endopeptidase inhibitor activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060297 | complement component 4a deficiency | |
| DOID:12306 | vitiligo | |
| DOID:12361 | Graves' disease | |
| DOID:4450 | renal cell carcinoma | |
| DOID:9074 | systemic lupus erythematosus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12268 | MGI:88228 | MOUSE20348 | ||
| 24233 | RGD:620005 | RATNO21691 | ||
| 280678 | BOVIN18738 | |||
| 394275 | Xenbase:XB-GENE-478885 | |||
| 406161 | RATNO21929 | |||
| 445467 | PIGXX31217 | |||
| 462577 | 9598_0:001c1a | PANTR37782 | ||
| 481722 | CANLF02580 | |||
| 566261 | ZFIN:ZDB-GENE-030131-5697 | DANRE08545 | ||
| 625018 | MGI:98320 | MOUSE20348 |
