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trio Rho guanine nucleotide exchange factor

Summary

Gene Symbol

TRIO

Organism

Homo sapiens (human)

External Links

NCBI Gene

7204

PubChem

7204

Alliance of Genome Resources

HGNC:12303

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell projection
Cytoplasm
Disease variant
Disulfide bond
Guanine-nucleotide releasing factor
Immunoglobulin domain
Intellectual disability
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
O75962	PTPRF-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of small GTPase mediated signal transduction	TAS
neuron projection morphogenesis	IMP	32109419
protein phosphorylation	IEA
postsynaptic modulation of chemical synaptic transmission	IDA IMP	26858404
axon guidance	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine phosphatase signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine phosphatase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

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GO Term	Evidence Code	PMID
postsynapse	IEA
cell projection	IEA
presynaptic active zone	IDA IMP	27907191
extrinsic component of membrane	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

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GO Term	Evidence Code	PMID
protein binding	IPI	17043677 19846667 21422296 22666460 31413325
protein serine kinase activity	IEA
guanyl-nucleotide exchange factor activity	IBA TAS
protein serine/threonine kinase activity	TAS	8643598
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rho guanine nucleotide exchange factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060307	autosomal dominant intellectual developmental disorder	Alliance of Genome Resources
DOID:0070074	autosomal dominant intellectual developmental disorder 44	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43974		FB:FBgn0024277
Caenorhabditis elegans	171988		WB:WBGene00006805
Mus musculus	223435		MGI:1927230	MOUSE15669
Rattus norvegicus	310192		RGD:1308360	RATNO24774
Danio rerio	368847		ZFIN:ZDB-GENE-030616-399
Pan troglodytes	461730	9598_0:001852		PANTR35065
Canis lupus familiaris	478610			CANLF13429
Xenopus laevis	496370		Xenbase:XB-GENE-6252075
Bos taurus	538292			BOVIN16150
Danio rerio	557667		ZFIN:ZDB-GENE-060503-334	DANRE16218