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D-2-hydroxyglutarate dehydrogenase

Summary

Gene Symbol

D2HGDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

728294

PubChem

728294

Alliance of Genome Resources

HGNC:28358

JoGo

D2HGDH

TogoVar

D2HGDH

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
FAD
Metal-binding
Mitochondrion
Oxidoreductase
Proteomics identification
Reference proteome
Signal
Transit peptide
Zinc

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B5MCV2
B3KSR6
B4E3K7
Q8N465

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
2-oxoglutarate metabolic process	TAS
malate metabolic process	IDA	33431826
response to manganese ion	ISS	15070399
response to zinc ion	ISS	15070399
protein metabolic process	ISS	15070399

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

primary metabolic process [inference]

protein metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	ISS	15070399
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	IDA	33431826
(R)-2-hydroxyglutarate dehydrogenase activity	ISS	15070399
(R)-2-hydroxyglutarate dehydrogenase activity	EXP	15070399
(R)-2-hydroxyglutarate dehydrogenase activity	IMP	20020533 33431826
FAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

(R)-2-hydroxyglutarate dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dehydrogenase

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
FAD binding
catalytic activity
flavin adenine dinucleotide binding
lactate oxidation
respiratory electron transport chain

Displaying **all 8** entries
InterPro
FAD linked oxidase, N-terminal
FAD-binding domain, PCMH-type
FAD-binding oxidoreductase/transferase, type 4, C-terminal
FAD-binding, type PCMH, subdomain 1
FAD-binding, type PCMH, subdomain 2
FAD-binding, type PCMH-like superfamily
FAD-linked oxidase-like, C-terminal
Vanillyl-alcohol oxidase, C-terminal subdomain 2