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tyrosine kinase 2

Summary

Gene Symbol

TYK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7297

PubChem

7297

Alliance of Genome Resources

HGNC:12440

Annotation

Keyword

3D-structure
ATP-binding
Phosphoprotein
Reference proteome
Repeat
SH2 domain
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P29597

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
positive regulation of NK T cell proliferation	IDA NAS	19088061
positive regulation of T-helper 17 type immune response	NAS	16482511
positive regulation of protein localization to nucleus	IDA	26479788 8605876
cellular response to virus	NAS	30936491
type I interferon-mediated signaling pathway	IDA NAS TAS	30936491 8232552

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of T-helper 17 type immune response [inference]

positive regulation of T-helper 17 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of T-helper 17 type immune response [inference]

positive regulation of T-helper 17 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	NAS TAS	11114383 34813358
cytoplasmic side of plasma membrane	IC	7528775
interleukin-23 receptor complex	NAS	12023369
extrinsic component of plasma membrane	TAS	34813358
nucleus	IDA	10502458

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

extrinsic component of cytoplasmic side of plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21516116 22939624 24704786 25416956 26175413 29892012 32296183 32953130
protein tyrosine kinase activity	EXP IC IDA TAS	10542297 1386289 7528775 7543512 8232552
growth hormone receptor binding	IBA IPI	10502458
non-membrane spanning protein tyrosine kinase activity	IBA IDA TAS	7526154 7657660 8232552 8605876
type 1 angiotensin receptor binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

angiotensin receptor binding [inference]

type 1 angiotensin receptor binding

cytokine receptor binding [inference]

growth hormone receptor binding

hormone receptor binding [inference]

growth hormone receptor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
ATP binding
cell differentiation
cytokine-mediated signaling pathway
growth hormone receptor binding
growth hormone receptor signaling pathway via JAK-STAT
kinase activity
non-membrane spanning protein tyrosine kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 5** entries
InterPro
FERM domain
Protein kinase domain
Protein kinase-like domain superfamily
SH2 domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0111989	immunodeficiency 35	Alliance of Genome Resources
DOID:14566	disease of cellular proliferation	Alliance of Genome Resources
DOID:2531	hematologic cancer	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 93 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32080		FB:FBgn0004864
Mus musculus	54721		MGI:1929470	MOUSE62710
Sus scrofa	397363			PIGXX18478
Xenopus laevis	444089		Xenbase:XB-GENE-993655
Pan troglodytes	455703	9598_0:004d09		PANTR17148
Canis lupus familiaris	476714			CANLF07861
Bos taurus	512484			BOVIN32596
Macaca mulatta	574130			MACMU20271
Ciona intestinalis	778659			CIOIN00444
Monodelphis domestica	100012931			MONDO20405

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements