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tyrosine kinase 2

Summary

Gene Symbol

TYK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7297

PubChem

7297

Alliance of Genome Resources

HGNC:12440

JoGo

TYK2

TogoVar

TYK2

Annotation

Keyword

3D-structure
ATP-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH2 domain
Tyrosine-protein kinase

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A8V8TN50
A0A8V8TPX5
H0YCT7
H0YE24
P29597

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
protein phosphorylation	TAS	2216457
immune response	NAS	19088061
receptor signaling pathway via JAK-STAT	TAS	8232552
receptor signaling pathway via JAK-STAT	IDA	7526154 7657660 8232552 8605876
cytokine-mediated signaling pathway	TAS

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of T-helper 17 type immune response [inference]

positive regulation of T-helper 17 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of T-helper 17 type immune response [inference]

positive regulation of T-helper 17 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 17 type immune response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

positive regulation of interleukin-17 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of natural killer cell proliferation [inference]

positive regulation of natural killer cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell activation [inference]

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

regulation of NK T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of natural killer cell activation [inference]

positive regulation of natural killer cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of natural killer cell proliferation

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell proliferation [inference]

positive regulation of NK T cell proliferation

positive regulation of NK T cell activation [inference]

positive regulation of NK T cell proliferation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	10502458
cytoplasm	IDA	10502458
cytosol	TAS
cytosol	IBA
cytoskeleton	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

extrinsic component of cytoplasmic side of plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein tyrosine kinase activity	EXP	1386289 8232552
protein tyrosine kinase activity	TAS	7528775
protein tyrosine kinase activity	IC	7543512
protein tyrosine kinase activity	IDA	10542297
non-membrane spanning protein tyrosine kinase activity	TAS	8232552

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

angiotensin receptor binding [inference]

type 1 angiotensin receptor binding

cytokine receptor binding [inference]

growth hormone receptor binding

hormone receptor binding [inference]

growth hormone receptor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
ATP binding
cell differentiation
cytokine-mediated signaling pathway
growth hormone receptor binding
growth hormone receptor signaling pathway via JAK-STAT
kinase activity
non-membrane spanning protein tyrosine kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying entries **1 - 10** of 14 in total

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InterPro
Band 4.1 domain
FERM F1 lobe ubiquitin-like domain
FERM domain
JAK, FERM F2 lobe domain
JAK1-3/TYK2, pleckstrin homology-like domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
SH2 domain superfamily
SH2 domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111989	immunodeficiency 35	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements