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thymidylate synthetase
Summary
- Gene Symbol
-
- TYMS
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Dyskeratosis congenita
- Isopeptide bond
- Methyltransferase
- Mitochondrion inner membrane
- Nucleotide biosynthesis
- Nucleus
- Phosphoprotein
- Reference proteome
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to toxic substance | ||
| response to folic acid | ||
| response to progesterone | ||
| response to vitamin A | ||
| developmental growth |
GO Hierarchy
- methylation
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
carbohydrate derivative metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
heterocycle biosynthetic process [inference]
response to stimulus [inference]
biological regulation [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| thymidylate synthase activity | ||
| sequence-specific mRNA binding | ||
| folic acid binding | ||
| protein homodimerization activity | ||
| mRNA regulatory element binding translation repressor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- thymidylate synthase
- Functional Category
-
- H: Coenzyme transport and metabolism
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:11054 | urinary bladder cancer | |
| DOID:1520 | colon carcinoma | |
| DOID:162 | cancer | |
| DOID:2729 | dyskeratosis congenita | |
| DOID:3526 | cerebral infarction | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:7148 | rheumatoid arthritis | |
| DOID:7693 | abdominal aortic aneurysm | |
| DOID:9119 | acute myeloid leukemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 22171 | MGI:98878 | MOUSE45811 | ||
| 29261 | RGD:3921 | RATNO43130 | ||
| 33499 | FB:FBgn0024920 | |||
| 81540 | ZFIN:ZDB-GENE-040426-59 | DANRE40656 | ||
| 172149 | WB:WBGene00022455 | |||
| 507631 | BOVIN19581 | |||
| 697580 | MACMU17583 | |||
| 740018 | 9598_0:0048c7 | PANTR15961 | ||
| 780313 | Xenbase:XB-GENE-1001385 | |||
| 854241 | SGD:S000005600 |
