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MIRAGE
complement C6

Summary
Gene Symbol
  • C6
Organism
Homo sapiens (human)
NCBI Gene
729
PubChem
729
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Direct protein sequencing
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Membrane attack complex
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Sushi
Proteins
Displaying 1 entry
UniProt Protein Name
P13671
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 6 - 7 of 7 in total
GO Term Evidence Code PMID
innate immune response
positive regulation of immune response
GO Hierarchy
Displaying 1 entry
GO Term Evidence Code PMID
protein binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
complement C6
Functional Category
  • K: Transcription
  • T: Signal transduction mechanisms
  • X: Mobilome: prophages, transposons
Displaying all 4 entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process
Displaying entries 1 - 10 of 13 in total
InterPro
Complement component C6, KAZAL domain
Complement components C8A/B/C6, EGF-like domain
Factor I / membrane attack complex
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Sushi/SCR/CCP domain
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:0060299 complement component 6 deficiency
Ortholog
Displaying entries 1 - 10 of 76 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
729 Xenbase:XB-GENE-974694
12274 MOUSE17264
24237 Xenbase:XB-GENE-974694 RATNO23574
393611 DANRE20523
449612 PANTR35646
479348 CANLF14986
507749 BOVIN15999
798694 DANRE20478
100018236 MONDO18227
100037952 PIGXX10537
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025