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ubiquitin like modifier activating enzyme 1

Summary

Gene Symbol

UBA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7317

PubChem

7317

Alliance of Genome Resources

HGNC:12469

JoGo

UBA1

TogoVar

UBA1

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative initiation
Cytoplasm
Direct protein sequencing
Disease variant
Ligase
Mitochondrion
Neurodegeneration
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P22314	Protein A1S9 Ubiquitin-activating enzyme E1
A0A024R1A3	Ubiquitin-activating enzyme E1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IBA
cellular response to DNA damage stimulus	IDA	22456334
DNA damage response	IDA	22456334
cellular response to DNA damage stimulus	IBA
DNA damage response	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
heterochromatin	IDA	1376922
nucleus	IDA	1376922 22456334
nucleus	IMP	33108101
nucleus	IBA
nucleus	HDA	21630459

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin [inference]

heterochromatin

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

rough endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
ubiquitin activating enzyme activity	TAS
ubiquitin activating enzyme activity	IDA	12629039 21685362
ubiquitin activating enzyme activity	IMP	33108101
ubiquitin activating enzyme activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

ubiquitin-like modifier activating enzyme activity [inference]

ubiquitin activating enzyme activity

catalytic activity, acting on a protein [inference]

ubiquitin-like modifier activating enzyme activity [inference]

ubiquitin activating enzyme activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ubiquitin-like modifier activating enzyme activity [inference]

ubiquitin activating enzyme activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin activating enzyme

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
ATP binding
ligase activity
nucleotide binding
protein ubiquitination
ubiquitin activating enzyme activity

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InterPro
THIF-type NAD/FAD binding fold
ThiF/MoeB/HesA family
Ubiquitin-activating enzyme E1, C-terminal domain superfamily
Ubiquitin-activating enzyme E1, C-terminal
Ubiquitin-activating enzyme E1, Cys active site
Ubiquitin-activating enzyme E1, FCCH domain superfamily
Ubiquitin-activating enzyme E1, FCCH domain
Ubiquitin-activating enzyme E1, SCCH domain
Ubiquitin-activating enzyme E1, four-helix bundle
Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1