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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

uncoupling protein 3

Summary

Gene Symbol

UCP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7352

PubChem

7352

Alliance of Genome Resources

HGNC:12519

Annotation

Keyword

Alternative splicing
Diabetes mellitus
Disease variant
Mitochondrion inner membrane
Obesity
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P55916	Solute carrier family 25 member 9 Uncoupling protein-3
A0A0S2Z4G5	Solute carrier family 25 member 9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
response to superoxide	IEA
response to hypoxia	IEA
lipid metabolic process	TAS	10935638
fatty acid metabolic process	IEA
response to nutrient	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

adaptive thermogenesis

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

mitochondrial transmembrane transport

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide

response to cold

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to activity

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to fenofibrate

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to ether [inference]

response to fenofibrate

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to ketone [inference]

response to fenofibrate

response to inorganic substance [inference]

response to oxygen radical [inference]

response to superoxide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide

response to ether [inference]

response to fenofibrate

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to ketone [inference]

response to fenofibrate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

mitochondrial transport [inference]

mitochondrial transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

mitochondrial transmembrane transport

organic substance transport [inference]

lipid transport [inference]

lipid hydroperoxide transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	HTP	34800366
mitochondrial inner membrane	ISS
mitochondrial inner membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	24008843
proton transmembrane transporter activity	IDA	11171965 12670931
calcium ion transmembrane transporter activity	IMP	21775425
oxidative phosphorylation uncoupler activity	IDA	11707458 36114012 9305858
oxidative phosphorylation uncoupler activity	IMP	21775425

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

oxidative phosphorylation uncoupler activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mitochondrial carrier

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Mitochondrial carrier domain superfamily
Mitochondrial substrate/solute carrier

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:11716	prediabetes syndrome	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources
DOID:9993	hypoglycemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7352	Xenbase:XB-GENE-6464668
Mus musculus	22229		MOUSE55493
Rattus norvegicus	25708		RATNO18311
Bos taurus	281563		BOVIN07215
Sus scrofa	397116		PIGXX34981
Canis lupus familiaris	403575		CANLF08278
Ovis aries	443278		SHEEP06492
Canis lupus familiaris	476808		CANLF08278
Macaca mulatta	574125		MACMU11236
Monodelphis domestica	619390		MONDO24683

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Last updated: April 7, 2025