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UDP-glucose pyrophosphorylase 2

Summary

Gene Symbol

UGP2

Aliases

SVUGP2
UGPP1
UTP--glucose-1-phosphate uridylyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

7360

HGNC

12527

KEGG Gene ID

hsa:7360

PubChem

7360

Alliance of Genome Resources

HGNC:12527

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Epilepsy
Magnesium
Metal-binding
Nucleotidyltransferase
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q16851	UDP-glucose pyrophosphorylase
A0A140VKE1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
UDP-glucose metabolic process	IBA IDA IMP	22132858 31820119 8354390 8631325
brain development	IMP	31820119
glycogen metabolic process	IBA
glycogen biosynthetic process	IEA IMP	31820119
glucose 1-phosphate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

phosphorus metabolic process [inference]

UDP-glucose metabolic process

phosphate-containing compound metabolic process [inference]

glucose 1-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 1-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organophosphate metabolic process [inference]

glucose 1-phosphate metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

glucose 1-phosphate metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

phosphorus metabolic process [inference]

UDP-glucose metabolic process

phosphate-containing compound metabolic process [inference]

glucose 1-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 1-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	HDA	21630459
cytosol	TAS
cytoplasm	IBA
extracellular exosome	HDA	19056867 20458337 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glucose binding	IEA
metal ion binding	IEA
UTP:glucose-1-phosphate uridylyltransferase activity	IBA IDA TAS	22132858 31820119 8354390
protein binding	IPI	16189514 17474147 25416956 32296183 32814053
pyrimidine ribonucleotide binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

uridylyltransferase activity [inference]

UTP-monosaccharide-1-phosphate uridylyltransferase activity [inference]

UTP:glucose-1-phosphate uridylyltransferase activity

binding [inference]

protein binding

identical protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

glucose binding

small molecule binding [inference]

monosaccharide binding [inference]

glucose binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

pyrimidine nucleotide binding [inference]

pyrimidine ribonucleotide binding

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

pyrimidine nucleotide binding [inference]

pyrimidine ribonucleotide binding

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000169764

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19889

H⁺ + UTP + α-D-glucose 1-phosphate

diphosphate + UDP-α-D-glucose

Enzyme

2.7.7.9

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

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DO ID	Disease Name	Source
DOID:0090049	paroxysmal nonkinesigenic dyskinesia 1	DisGeNET
DOID:0111459	classic galactosemia	DisGeNET
DOID:0112218	developmental and epileptic encephalopathy 83	Alliance of Genome Resources
DOID:1324	lung cancer	DisGeNET
DOID:14695	galactokinase deficiency	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET Alliance of Genome Resources
DOID:1793	pancreatic cancer	DisGeNET
DOID:2747	glycogen storage disease	DisGeNET
DOID:2749	glycogen storage disease Ia	DisGeNET
DOID:2862	glucosephosphate dehydrogenase deficiency	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 31 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000286	Epicanthus
HP:0000340	Sloping forehead
HP:0000341	Narrow forehead
HP:0000343	Long philtrum
HP:0000369	Low-set ears
HP:0000639	Nystagmus
HP:0000664	Synophrys
HP:0000817	Reduced eye contact

Displaying 1 entry
Disease ID	Disease Name
OMIM:618744	developmental and epileptic encephalopathy, 83

PubChem Disease

MedGen Diseases

Developmental and epileptic encephalopathy, 83

OMIM Phenotypes

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 83; DEE83

KEGG Diseases

Early infantile epileptic encephalopathy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Papio anubis	101021917	PAPAN09555
Mandrillus leucophaeus	105544715	MANLE19510
Gorilla gorilla gorilla	101138025	GORGO24510
Pan paniscus	100980155	PANPA24895
Pan troglodytes	459273	PANTR27727
Pongo abelii	100173462	PONAB22551
Canis lupus familiaris	474615	CANLF01880
Vulpes vulpes	112915295	VULVU06928
Ursus americanus	123785982	URSAM00464
Mustela putorius furo	101676847	MUSPF17751

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External Links

Annotation

PubChem Disease

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Acknowledgements