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Guidelines

MIRAGE

tubulin, beta 2B class IIB

Summary

Gene Symbol

Tubb2b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

73710

PubChem

73710

Alliance of Genome Resources

MGI:1920960

Annotation

Keyword

Acetylation
Cytoskeleton
Direct protein sequencing
GTP-binding
Isopeptide bond
Magnesium
Metal-binding
Methylation
Microtubule
Neurogenesis
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9CWF2
B2RSN3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
neuron migration	ISO
neuron migration	IBA
neuron migration	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

cell cycle [inference]

mitotic cell cycle

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

animal organ development [inference]

embryonic organ development [inference]

embryonic brain development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

regulation of axon guidance [inference]

positive regulation of axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
microtubule	ISO
microtubule	IBA
microtubule	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intercellular bridge

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
GTPase activity	IEA
structural constituent of cytoskeleton	IBA
structural constituent of cytoskeleton	IEA
GTP binding	IBA
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin beta-2A chain

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 10** entries
InterPro
Beta tubulin, autoregulation binding site
Beta tubulin
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090132	complex cortical dysplasia with other brain malformations 7	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **131** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7280	Xenbase:XB-GENE-491121	HUMAN82946
Saccharomyces cerevisiae S288C	10381	SGD:S000001857
Saccharomyces cerevisiae S288C	10382	SGD:S000001857
Saccharomyces cerevisiae S288C	10383	SGD:S000001857
Xenopus tropicalis	22151	Xenbase:XB-GENE-491121
Saccharomyces cerevisiae S288C	22152	SGD:S000001857
Saccharomyces cerevisiae S288C	22153	SGD:S000001857
Saccharomyces cerevisiae S288C	22154	SGD:S000001857
Saccharomyces cerevisiae S288C	67951	SGD:S000001857
Xenopus tropicalis	73710	Xenbase:XB-GENE-491121

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025