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ubiquinol-cytochrome c reductase core protein 1

Summary

Gene Symbol

UQCRC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7384

PubChem

7384

Alliance of Genome Resources

HGNC:12585

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Mitochondrion inner membrane
Neuropathy
Parkinsonism
Phosphoprotein
Reference proteome
Respiratory chain
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P31930	Complex III subunit 1 Core protein I Ubiquinol-cytochrome-c reductase complex core protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
aerobic respiration	TAS	8407948
mitochondrial electron transport, ubiquinol to cytochrome c	NAS	28844695
oxidative phosphorylation	TAS	8407948
response to alkaloid	IEA
response to activity	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

response to stimulus [inference]

response to activity

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA TAS	28844695
mitochondrial respirasome
respiratory chain complex III	IEA
mitochondrion	HDA HTP IBA IDA	20833797 34800366
mitochondrial respiratory chain complex III

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

respiratory chain complex

respiratory chain complex III

mitochondrial respiratory chain complex III

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

oxidoreductase complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

respirasome [inference]

mitochondrial respirasome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32161263 32814053 35101990
protein-containing complex binding	IEA
metal ion binding	IEA
ubiquinol-cytochrome-c reductase activity	TAS	8407948
ubiquitin protein ligase binding	IPI	19725078

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

ubiquinol-cytochrome-c reductase activity

oxidoreductase activity, acting on diphenols and related substances as donors [inference]

ubiquinol-cytochrome-c reductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
protein processing involved in protein targeting to mitochondrion
proteolysis

Displaying **all 4** entries
InterPro
Metalloenzyme, LuxS/M16 peptidase-like
Peptidase M16, C-terminal
Peptidase M16, N-terminal
Peptidase M16, zinc-binding site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060892	late onset Parkinson's disease	Alliance of Genome Resources
DOID:0070332	multiple mitochondrial dysfunctions syndrome 6	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22273		MGI:107876	MOUSE64423
Drosophila melanogaster	41800		FB:FBgn0038271
Caenorhabditis elegans	175772		WB:WBGene00018963
Caenorhabditis elegans	177725		WB:WBGene00013880
Bos taurus	282393			BOVIN17875
Rattus norvegicus	301011		RGD:1303314	RATNO40729
Xenopus laevis	379401		Xenbase:XB-GENE-6255826
Danio rerio	393793		ZFIN:ZDB-GENE-040426-1792
Pan troglodytes	460348	9598_0:0011b1		PANTR31067
Xenopus tropicalis	549464		Xenbase:XB-GENE-5905304

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Annotation

OrthoDB (Group)

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Acknowledgements