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ubiquinol-cytochrome c reductase core protein 2

Summary

Gene Symbol

UQCRC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7385

PubChem

7385

Alliance of Genome Resources

HGNC:12586

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Mitochondrion inner membrane
Primary mitochondrial disease
Reference proteome
Respiratory chain
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P22695	Complex III subunit 2 Core protein II Ubiquinol-cytochrome-c reductase complex core protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
aerobic respiration	TAS	8288258
proteolysis	IEA
mitochondrial electron transport, ubiquinol to cytochrome c	NAS	28844695
oxidative phosphorylation	TAS	8288258
cellular respiration	NAS	28844695

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA TAS	28844695
nucleoplasm	IDA
respiratory chain complex III	IDA	23168492 31536960
mitochondrion	HDA HTP IBA IDA	20833797 34800366
mitochondrial respiratory chain complex III

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

respiratory chain complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

oxidoreductase complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21078624 31536960 32814053 35101990
metal ion binding	IEA
metalloendopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome b-c1 complex subunit 2

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 3** entries
InterPro
Metalloenzyme, LuxS/M16 peptidase-like
Peptidase M16, C-terminal
Peptidase M16, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060399	chromosome 16p12.1 deletion syndrome	Alliance of Genome Resources
DOID:0080114	mitochondrial complex III deficiency nuclear type 5	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39846		FB:FBgn0250814
Mus musculus	67003		MGI:1914253	MOUSE56191
Caenorhabditis elegans	175248		WB:WBGene00020757
Bos taurus	282394			BOVIN20427
Rattus norvegicus	293448		RGD:1359150	RATNO21007
Danio rerio	322549		ZFIN:ZDB-GENE-030131-1269	DANRE03578
Xenopus laevis	380093		Xenbase:XB-GENE-17334056
Danio rerio	436930		ZFIN:ZDB-GENE-040718-405
Xenopus laevis	446522		Xenbase:XB-GENE-976158
Pan troglodytes	468094	9598_0:0040b8		PANTR11927

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements