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solute carrier family 25, member 27

Summary

Gene Symbol

Slc25a27

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74011

PubChem

74011

Alliance of Genome Resources

MGI:1921261

Annotation

Keyword

Cell projection
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D6D0	Solute carrier family 25, member 27

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	ISO
negative regulation of mitochondrial calcium ion concentration	ISO
intracellular triglyceride homeostasis	ISO
chloride transmembrane transport	IEA
response to cold	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

proton transmembrane transport

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular triglyceride homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular triglyceride homeostasis

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis [inference]

intracellular triglyceride homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

response to stimulus [inference]

response to stress [inference]

response to cold

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

proton transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

negative regulation of membrane potential [inference]

negative regulation of mitochondrial membrane potential

regulation of mitochondrial membrane potential [inference]

negative regulation of mitochondrial membrane potential

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA	25237189
neuronal cell body	ISO
neuron projection	IEA
mitochondrion	HDA IDA ISO	14651853 18614015 19646951
apical part of cell	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

cell body [inference]

neuronal cell body

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
chloride transmembrane transporter activity	IEA ISO
proton transmembrane transporter activity	IEA ISO
transmembrane transporter activity	IBA
protein homodimerization activity	IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

mitochondrial uncoupling protein 4

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
response to cold

Displaying **all 2** entries
InterPro
Mitochondrial carrier domain superfamily
Mitochondrial substrate/solute carrier

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9481		HGNC:21065	HUMAN85092
Drosophila melanogaster	32764		FB:FBgn0030872
Drosophila melanogaster	33832		FB:FBgn0031757
Drosophila melanogaster	33833		FB:FBgn0031758
Rattus norvegicus	85262	10116_1:003122	RGD:620787	RATNO42500
Caenorhabditis elegans	179315		WB:WBGene00006729
Danio rerio	393312		ZFIN:ZDB-GENE-040426-1290	DANRE20047
Pan troglodytes	472019			PANTR38308
Xenopus tropicalis	496683		Xenbase:XB-GENE-1005902
Bos taurus	536813			BOVIN18605