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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
lysine demethylase 6A
Summary
- Gene Symbol
-
- KDM6A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Chromatin regulator
- Dioxygenase
- Intellectual disability
- Iron
- Metal-binding
- Methylation
- Nucleus
- Oxidoreductase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- TPR repeat
- Zinc
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| heart development | ||
| regulation of gene expression | ||
| chromatin remodeling |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm | ||
| histone methyltransferase complex | ||
| MLL3/4 complex | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| histone demethylase activity | ||
| histone H3K27me2/H3K27me3 demethylase activity | ||
| metal ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- lysine-specific demethylase
- Functional Category
-
- K: Transcription
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| chromatin DNA binding |
| histone H3K27me2/H3K27me3 demethylase activity |
| InterPro |
|---|
| Tetratricopeptide repeat |
| Tetratricopeptide-like helical domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060081 | triple-receptor negative breast cancer | |
| DOID:0060473 | Kabuki syndrome | |
| DOID:0080188 | chronic myelomonocytic leukemia | |
| DOID:0080202 | adenoid cystic carcinoma | |
| DOID:10283 | prostate cancer | |
| DOID:10534 | stomach cancer | |
| DOID:1574 | alcohol use disorder | |
| DOID:1612 | breast cancer | |
| DOID:1996 | rectum adenocarcinoma | |
| DOID:234 | colon adenocarcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 22289 | MGI:1095419 | MOUSE66600 | ||
| 34377 | FB:FBgn0260749 | |||
| 280952 | BOVIN37190 | |||
| 446609 | Xenbase:XB-GENE-960319 | |||
| 465593 | 9598_0:0057e6 | PANTR45839 | ||
| 491845 | CANLF19711 | |||
| 569207 | ZFIN:ZDB-GENE-070112-2002 | DANRE38740 | ||
| 569277 | ZFIN:ZDB-GENE-081105-56 | DANRE44687 | ||
| 852410 | SGD:S000000316 | |||
| 100016846 | MONDO21889 |
