GlyCosmos Portal

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GO Term	Evidence Code	PMID
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
protein binding	IPI	17178841 24981860 27705803 32296183 33961781 34667079
chromatin DNA binding	IBA
histone demethylase activity	TAS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding [inference]

chromatin DNA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

chromatin DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysine-specific demethylase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
chromatin DNA binding
histone H3K27me2/H3K27me3 demethylase activity

Displaying **all 2** entries
InterPro
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0060081	triple-receptor negative breast cancer	Alliance of Genome Resources
DOID:0060473	Kabuki syndrome	Alliance of Genome Resources
DOID:0080202	adenoid cystic carcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4006	bladder urothelial carcinoma	Alliance of Genome Resources
DOID:5409	lung small cell carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7403	Xenbase:XB-GENE-960316
Xenopus tropicalis	7404	Xenbase:XB-GENE-960316
Mus musculus	22289	Xenbase:XB-GENE-960316	MOUSE66600
Saccharomyces cerevisiae S288C	23135	SGD:S000000316
Saccharomyces cerevisiae S288C	216850	SGD:S000000316
Bos taurus	280952		BOVIN37190
Pan troglodytes	465593		PANTR45839
Canis lupus familiaris	491845		CANLF19711
Danio rerio	569207		DANRE38740
Danio rerio	569277		DANRE44687

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements