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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
vinculin
Summary
- Gene Symbol
-
- VCL
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Actin-binding
- Alternative splicing
- Cardiomyopathy
- Cell adhesion
- Cell junction
- Cell membrane
- Cell projection
- Coiled coil
- Cytoplasm
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Palmitate
- Phosphoprotein
- Reference proteome
- Repeat
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| morphogenesis of an epithelium | ||
| cell-matrix adhesion | ||
| lamellipodium assembly | ||
| maintenance of blood-brain barrier | ||
| regulation of protein localization to adherens junction |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| secretory granule lumen | ||
| focal adhesion | ||
| sarcolemma | ||
| podosome ring | ||
| protein-containing complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| actin binding | ||
| alpha-catenin binding | ||
| dystroglycan binding | ||
| beta-catenin binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Uncharacterized protein
- Functional Category
-
- G: Carbohydrate transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| actin binding |
| actin filament binding |
| alpha-catenin binding |
| beta-catenin binding |
| InterPro |
|---|
| Alpha-catenin/vinculin-like superfamily |
| Vinculin/alpha-catenin |
| Vinculin |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110321 | hypertrophic cardiomyopathy 15 | |
| DOID:0110446 | dilated cardiomyopathy 1W | |
| DOID:11984 | hypertrophic cardiomyopathy | |
| DOID:12930 | dilated cardiomyopathy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 22330 | MGI:98927 | MOUSE13769 | ||
| 31201 | FB:FBgn0004397 | |||
| 177482 | WB:WBGene00000942 | |||
| 305679 | RGD:1311217 | RATNO10563 | ||
| 373770 | Xenbase:XB-GENE-5759162 | |||
| 396974 | PIGXX07854 | |||
| 450531 | 9598_0:002ae0 | PANTR00938 | ||
| 479252 | CANLF14688 | |||
| 552980 | ZFIN:ZDB-GENE-050506-61 | |||
| 721921 | MACMU45808 |
