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tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Summary

Gene Symbol

Tnks2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74493

PubChem

74493

Alliance of Genome Resources

MGI:1921743

Annotation

Keyword

ADP-ribosylation
ANK repeat
Cytoplasm
Glycosyltransferase
Golgi apparatus
Hydroxylation
Membrane
Metal-binding
NAD
Nucleotidyltransferase
Nucleus
Reference proteome
Repeat
Telomere
Ubl conjugation
Wnt signaling pathway
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3UES3	ADP-ribosyltransferase diphtheria toxin-like 6 Protein poly-ADP-ribosyltransferase tankyrase-2 TNKS-2 TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Tankyrase II Tankyrase-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
telomere maintenance	IMP ISS	16507984 16507985
protein poly-ADP-ribosylation	ISO
positive regulation of telomere capping	IBA ISO
protein auto-ADP-ribosylation	ISO
Wnt signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

multicellular organismal process [inference]

multicellular organism growth

growth [inference]

developmental growth [inference]

multicellular organism growth

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of telomere capping [inference]

positive regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

negative regulation of telomere maintenance via telomere lengthening

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere maintenance via telomere lengthening

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere capping

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IBA ISO
pericentriolar material	ISO
nuclear envelope	ISO
chromosome	IEA
cytoplasm	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

perinuclear region of cytoplasm

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IBA ISO
glycosyltransferase activity	IEA
transferase activity	IEA
NAD+-protein ADP-ribosyltransferase activity	ISO
enzyme binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

pentosyltransferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **21 - 30** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gorilla gorilla gorilla	101139351		GORGO01119
Pan paniscus	100984841		PANPA05141
Pan troglodytes	100609110		PANTR01139
Pongo abelii	100432166		PONAB01208
Homo sapiens	80351	HGNC:15677	HUMAN02133
Vulpes vulpes	112913786		VULVU00562
Ursus americanus	123800270		URSAM15598
Ailuropoda melanoleuca	100464558		AILME16010
Mustela putorius furo	101676482		MUSPF14813
Panthera leo	122201631		PANLE03344

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements