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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
sclerostin
Summary
- Gene Symbol
-
- Sost
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Heparin-binding
- Reference proteome
- Signal
- Wnt signaling pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99P68 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| canonical Wnt signaling pathway | ||
| cellular response to parathyroid hormone stimulus | ||
| BMP signaling pathway | ||
| positive regulation of transcription, DNA-templated | ||
| negative regulation of BMP signaling pathway |
GO Hierarchy
- localization
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| protein-containing complex | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| heparin binding | ||
| DNA-binding transcription factor binding | ||
| molecular function inhibitor activity | ||
| BMP binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- sclerostin
- Functional Category
-
- K: Transcription
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| BMP binding |
| heparin binding |
| ossification |
| InterPro |
|---|
| Cystine-knot cytokine |
| Sclerostin/Sclerostin domain-containing protein 1 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060251 | sclerosteosis | |
| DOID:0060756 | sclerosteosis 1 | |
| DOID:0080036 | SOST-related sclerosing bone dysplasia | |
| DOID:0080807 | autosomal dominant craniodiaphyseal dysplasia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 131917779 | 42410_0:002d2b |
