GlyCosmos Portal

Annotation

Keyword

Calcium
Cell membrane
Cell projection
Endosome
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Spinocerebellar ataxia
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y4D2	Neural stem cell-derived dendrite regulator Sn1-specific diacylglycerol lipase alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
diacylglycerol catabolic process	IBA IDA IMP	14610053 23502535
arachidonic acid metabolic process	IBA IDA TAS	14610053
regulation of neuroinflammatory response	ISS
G protein-coupled glutamate receptor signaling pathway
monoacylglycerol biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IBA
postsynaptic density membrane	IDA	27595600
plasma membrane	TAS
dendritic spine membrane	ISS
varicosity	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

leading edge membrane [inference]

neuron projection membrane [inference]

varicosity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23502535 32296183
acylglycerol lipase activity	TAS
lipoprotein lipase activity	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

carboxylic ester hydrolase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lipase A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
lipid metabolic process

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Fungal lipase-like domain

Rhea

RHEA:33275

H₂O + a 1,2-diacyl-sn-glycerol

H⁺ + a 2-acylglycerol + a fatty acid

Enzyme

3.1.1.116

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1324	lung cancer	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003827
Gene Name: diacylglycerol lipase, alpha

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32343		FB:FBgn0261244
Mus musculus	269060		MGI:2677061	MOUSE26001
Rattus norvegicus	309207		RGD:1359461	RATNO16572
Pan troglodytes	451241	9598_0:00304d		PANTR03098
Bos taurus	523665			BOVIN23242
Danio rerio	569398		ZFIN:ZDB-GENE-070619-1
Macaca mulatta	722350			MACMU09065
Caenorhabditis elegans	3565075		WB:WBGene00018364
Equus caballus	100059772			HORSE06089
Ornithorhynchus anatinus	100091533			ORNAN17488

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements