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arachidonate 15-lipoxygenase

Summary

Gene Symbol

ALOX15

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 748294
KEGG Gene ID: ptr:748294
PubChem: 748294

Annotation

Keyword

Calcium
Cytoplasm
Dioxygenase
Iron
Lipid droplet
Lipid metabolism
Lipid-binding
Membrane
Metal-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6D2X3B0	12/15-lipoxygenase Arachidonate 12-lipoxygenase, leukocyte-type Arachidonate 15-lipoxygenase Arachidonate omega-6 lipoxygenase Hepoxilin A3 synthase Alox15 Linoleate 13S-lipoxygenase
A0A2J8KQU9	12/15-lipoxygenase Arachidonate 12-lipoxygenase, leukocyte-type Arachidonate 15-lipoxygenase Arachidonate omega-6 lipoxygenase Hepoxilin A3 synthase Alox15 Linoleate 13S-lipoxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hepoxilin biosynthetic process	IEA	30032202
arachidonic acid metabolic process	IEA	30032202
lipid oxidation	IEA	30032202
lipoxygenase pathway	IEA	30032202
linoleic acid metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IEA	30032202
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
arachidonate 15-lipoxygenase activity	IEA	30032202
arachidonate 12(S)-lipoxygenase activity	IEA	30032202
iron ion binding	IEA	22301074
protein binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00460

Name

arachidonate 15-lipoxygenase [EC:1.13.11.33]

References

Rhea

RHEA:22780

O₂ + (9Z,12Z)-octadecadienoate

(13S)-hydroperoxy-(9Z,11E)-octadecadienoate

Enzyme

1.13.11.12

PMID

RHEA:34495

O₂ + (9Z,12Z,15Z)-octadecatrienoate

(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate

Enzyme

1.13.11.12

PMID

RHEA:10428

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Enzyme

1.13.11.31

PMID

RHEA:16869

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Enzyme

1.13.11.33

PMID

Ortholog

Displaying entries **1 - 10** of 34 in total

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Species	Gene ID	Orthologous MAtrix
Ciona intestinalis	100179479	CIOIN02039
Callithrix jacchus	100388086	CALJA36167
Macaca mulatta	709212	MACMU16253
Macaca nemestrina	105472240	MACNE31817
Papio anubis	101014249	PAPAN13295
Mandrillus leucophaeus	105539984	MANLE29568
Gorilla gorilla gorilla	101130490	GORGO12616
Pan paniscus	100990568	PANPA16081
Pongo abelii	100174413	PONAB12818
Homo sapiens	246	HUMAN30940

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KEGG BRITE Database

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Acknowledgements