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exportin 1

Summary

Gene Symbol

XPO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7514

PubChem

7514

Alliance of Genome Resources

HGNC:12825

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Protein transport
Proteomics identification
RNA-binding
Reference proteome
Repeat
mRNA transport

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B3KWD0
A0A7I2V6B9
A0A7I2V461
A0A7I2V2Y6
O14980	Chromosome region maintenance 1 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
ribosomal subunit export from nucleus	IMP	12724356
ribosomal large subunit export from nucleus	IMP	12773398
ribosomal large subunit export from nucleus	IBA
ribosomal small subunit export from nucleus	IMP	12773398
ribosomal small subunit export from nucleus	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

cellular component organization or biogenesis [inference]

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosome biogenesis

localization [inference]

protein-containing complex localization [inference]

ribosomal subunit export from nucleus

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

organelle localization [inference]

ribosome localization [inference]

ribosomal subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cellular component organization [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	17363900
nucleus	IBA
nuclear envelope	TAS	9368044
annulate lamellae	IDA	12210765
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex

ribonucleoprotein complex

cellular anatomical entity [inference]

membrane

annulate lamellae

organelle membrane [inference]

nuclear membrane

nuclear body [inference]

Cajal body

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

supramolecular complex [inference]

kinetochore

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
RNA binding	IEA
nuclear export signal receptor activity	ISS	31340148
nuclear export signal receptor activity	TAS
nuclear export signal receptor activity	IDA	29666234
nuclear export signal receptor activity	IMP	12724356 12773398

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular carrier activity [inference]

nucleocytoplasmic carrier activity [inference]

nuclear export signal receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

exportin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Chromosome region maintenance repeat
Exportin-1, C-terminal
Exportin-1, repeat 2
Exportin-1, repeat 3
Exportin-1/5
Exportin-1/Importin-beta-like
Importin-beta, N-terminal domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7514	Xenbase:XB-GENE-993240
Rattus norvegicus	85252		RATNO08749
Mus musculus	103573		MOUSE03135
Sus scrofa	397330		PIGXX21983
Pan troglodytes	459534		PANTR27700
Canis lupus familiaris	474609		CANLF01869
Bos taurus	510568		BOVIN02618
Macaca mulatta	718063		MACMU07878
Monodelphis domestica	100013094		MONDO07461
Monodelphis domestica	100031924		MONDO07461