GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Autism
Brugada syndrome
Calcium channel
Calmodulin-binding
Cell membrane
Cell projection
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Host-virus interaction
Intellectual disability
Long QT syndrome
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Proteins

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UniProt	Protein Name
E9PDI6
Q59GU3
A0A0A0MR67
A0A804HI37
A0A804HKC4
A0A804HIJ8
A0A804HJB6
A0A0A0MSA1
F5H522
Q5V9X9

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
immune system development	IMP	15454078
positive regulation of cytosolic calcium ion concentration	IDA	12130699
heart development	IMP	15454078
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	TAS	11576544

GO Hierarchy

biological process

immune system process [inference]

immune system development

cellular process [inference]

cell communication [inference]

cell communication by electrical coupling [inference]

cell communication by electrical coupling involved in cardiac conduction

cell communication involved in cardiac conduction [inference]

cell communication by electrical coupling involved in cardiac conduction

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

forelimb morphogenesis [inference]

embryonic forelimb morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

heart development

system development [inference]

immune system development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane import into cytosol [inference]

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

positive regulation of muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

cardiac conduction

regulation of heart rate by cardiac conduction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

positive regulation of cytosolic calcium ion concentration

calcium ion transport into cytosol

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

membrane depolarization [inference]

membrane depolarization during action potential [inference]

membrane depolarization during cardiac muscle cell action potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytoplasm	IDA	11206130
plasma membrane	ISS
plasma membrane	TAS
plasma membrane	IDA	11206130

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

cilium

postsynaptic specialization [inference]

postsynaptic density

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GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	IDA	11741969 12130699 12176756 16299511 17071743 28119464 29078335 7737988 8392192 9013606 9087614 9607315
voltage-gated calcium channel activity	IMP	15863612 20953164 24728418 25260352 27218670 31430211 8099908
protein binding	IPI	11438518 15140941 18535142 21134641 21653829 37207277
calmodulin binding	IPI	15140941
high voltage-gated calcium channel activity	TAS	11576544

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

voltage-gated calcium channel activity involved in AV node cell action potential

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actinin binding [inference]

alpha-actinin binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent calcium channel

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
high voltage-gated calcium channel activity
metal ion binding
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Ion transport domain
Voltage-dependent channel domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060173	Timothy syndrome	Alliance of Genome Resources
DOID:0070536	neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Alliance of Genome Resources
DOID:0110220	Brugada syndrome 3	Alliance of Genome Resources
DOID:0110649	long QT syndrome 8	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	773	SGD:S000003449
Saccharomyces cerevisiae S288C	774	SGD:S000003449
Xenopus tropicalis	775	Xenbase:XB-GENE-991126
Saccharomyces cerevisiae S288C	776	SGD:S000003449
Saccharomyces cerevisiae S288C	777	SGD:S000003449
Saccharomyces cerevisiae S288C	778	SGD:S000003449
Saccharomyces cerevisiae S288C	779	SGD:S000003449
Saccharomyces cerevisiae S288C	6323	SGD:S000003449
Saccharomyces cerevisiae S288C	6326	SGD:S000003449
Saccharomyces cerevisiae S288C	6328	SGD:S000003449

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements