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Guidelines
MIRAGE
LDL receptor related protein 8

Summary
Gene Symbol
  • LRP8
Organism
Homo sapiens (human)
NCBI Gene
7804
PubChem
7804
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Disulfide bond
  • EGF-like domain
  • Endocytosis
  • Glycoprotein
  • Host-virus interaction
  • Metal-binding
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Proteins
Displaying 1 entry
UniProt Protein Name
Q14114
  • Apolipoprotein E receptor 2
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 21 in total
GO Term Evidence Code PMID
retinoid metabolic process
proteolysis
lipid metabolic process
endocytosis
signal transduction
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Low-density lipoprotein receptor
Functional Category
  • G: Carbohydrate transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
calcium ion binding
Displaying entries 1 - 10 of 11 in total
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
NOTCH1 EGF-like calcium-binding domain
Disease
Disease Ontology
Displaying all 5 entries
DO ID Disease Name Source
DOID:10652 Alzheimer's disease
DOID:1307 dementia
DOID:3393 coronary artery disease
DOID:5419 schizophrenia
DOID:5844 myocardial infarction
Ortholog
Displaying entries 11 - 20 of 58 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
489584 CANLF15694
557734 DANRE37624
714317 MACMU22447
100219357 TAEGU28796
100345692 RABIT03895
100415376 CALJA39603
100442107 PONAB18396
100542284 MELGA02442
100604448 NOMLE37619
100729013 CAVPO25201
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025