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Standards Ontologies Notations
calcium voltage-gated channel auxiliary subunit beta 2

Summary
Gene Symbol
  • CACNB2
Organism
Homo sapiens (human)
NCBI Gene
783
PubChem
783
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Brugada syndrome
  • Calcium channel
  • Cell membrane
  • Disease variant
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH3 domain
  • Voltage-gated channel
Proteins
Displaying all 4 entries
UniProt Protein Name
A0A494C184
  • Calcium channel voltage-dependent subunit beta 2
Q59H42
  • Calcium channel voltage-dependent subunit beta 2
Q5VVH1
  • Calcium channel voltage-dependent subunit beta 2
Q08289
  • Calcium channel voltage-dependent subunit beta 2
  • Lambert-Eaton myasthenic syndrome antigen B
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 15 in total
GO Term Evidence Code PMID
positive regulation of high voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of muscle contraction
membrane depolarization during atrial cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
GO Hierarchy
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
protein binding
actin filament binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
calcium channel activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Voltage-dependent calcium channel, L-type, beta subunit
Functional Category
  • G: Carbohydrate transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
calcium ion transmembrane transport
Displaying all 5 entries
InterPro
Guanylate kinase/L-type calcium channel beta subunit
P-loop containing nucleoside triphosphate hydrolase
SH3-like domain superfamily
Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
Voltage-dependent calcium channel, L-type, beta subunit
Disease
Disease Ontology
Displaying all 3 entries
DO ID Disease Name Source
DOID:0110221 Brugada syndrome 4
DOID:10763 hypertension
DOID:11984 hypertrophic cardiomyopathy
Ortholog
Displaying entries 1 - 10 of 75 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
12296 MGI:894644 MOUSE32513
116600 RGD:67385 RATNO12483
171933 WB:WBGene00000368
327667 BOVIN04484
487113 CANLF06523
558806 ZFIN:ZDB-GENE-050208-129
701226 MACMU45112
740138 9598_0:002df1 PANTR00263
795492 ZFIN:ZDB-GENE-080808-7
100009277 RABIT05659
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024