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MIRAGE
calcium voltage-gated channel auxiliary subunit beta 2

Summary
Gene Symbol
  • CACNB2
Organism
Homo sapiens (human)
NCBI Gene
783
PubChem
783
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Brugada syndrome
  • Calcium channel
  • Cell membrane
  • Disease variant
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH3 domain
  • Voltage-gated channel
Proteins
Displaying all 4 entries
UniProt Protein Name
A0A494C184
  • Calcium channel voltage-dependent subunit beta 2
Q59H42
  • Calcium channel voltage-dependent subunit beta 2
Q5VVH1
  • Calcium channel voltage-dependent subunit beta 2
Q08289
  • Calcium channel voltage-dependent subunit beta 2
  • Lambert-Eaton myasthenic syndrome antigen B
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 15 in total
GO Term Evidence Code PMID
calcium ion transport
chemical synaptic transmission
neuromuscular junction development
visual perception
positive regulation of muscle contraction
GO Hierarchy
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
voltage-gated calcium channel activity
calcium channel activity
protein binding
high voltage-gated calcium channel activity
actin filament binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
voltage-dependent l-type calcium channel subunit
Functional Category
  • G: Carbohydrate transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
calcium ion transmembrane transport
Displaying all 5 entries
InterPro
Guanylate kinase/L-type calcium channel beta subunit
P-loop containing nucleoside triphosphate hydrolase
SH3-like domain superfamily
Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
Voltage-dependent calcium channel, L-type, beta subunit
Disease
Disease Ontology
Displaying all 3 entries
DO ID Disease Name Source
DOID:0110221 Brugada syndrome 4
DOID:10763 hypertension
DOID:11984 hypertrophic cardiomyopathy
Ortholog
Displaying entries 1 - 10 of 73 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
782 WB:WBGene00000368
783 Xenbase:XB-GENE-962360
12295 WB:WBGene00000368
12296 MOUSE32513
12297 WB:WBGene00000368
12298 WB:WBGene00000368
116600 RATNO12483
327667 BOVIN04484
487113 CANLF06523
701226 MACMU45112
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025