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peroxidasin

Summary

Gene Symbol

PXDN

Organism

Homo sapiens (human)

External Links

NCBI Gene

7837

PubChem

7837

Alliance of Genome Resources

HGNC:14966

Annotation

Keyword

Alternative splicing
Basement membrane
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Heme
Hydrogen peroxide
Immunoglobulin domain
Leucine-rich repeat
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92626	Melanoma-associated antigen MG50 Peroxidasin 1 Vascular peroxidase 1 p53-responsive gene 2 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
cellular oxidant detoxification	IEA
immune response	NAS	11103812
negative regulation of cytokine-mediated signaling pathway	IEA
cell adhesion	ISS
extracellular matrix organization	IDA	19590037

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell adhesion

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

supramolecular fiber organization [inference]

collagen fibril organization

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IDA	26178375
collagen-containing extracellular matrix	HDA IDA	19590037 23979707 28327460
basement membrane	ISS
extracellular region	TAS
cell surface	IDA	25708780

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
laminin-1 binding	IDA	32485152
heme binding	IDA	18929642
oxidoreductase activity, acting on peroxide as acceptor	IDA IMP	22842973 27697841 32571911

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor

peroxidase activity

lactoperoxidase activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-1 receptor antagonist activity

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

growth factor binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

cytokine binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

laminin binding [inference]

laminin-1 binding

ion binding [inference]

cation binding [inference]

metal ion binding

extracellular matrix binding [inference]

laminin binding [inference]

laminin-1 binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

lactoperoxidase activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080612	anterior segment dysgenesis 7	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of 93 in total

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Species	Gene ID	Orthologous MAtrix
Echeneis naucrates	115036054	ECHNA39339
Salmo trutta	115162487	SALTR56545
Salmo trutta	115172777	SALTR73209
Gadus morhua	115543712	GADMO49050
Sparus aurata	115565832	SPAAU04124
Strigops habroptila	115609449	STRHB17165
Corvus moneduloides	116442016	CORMO18475
Chelonoidis abingdonii	116831249	CHEAB12597
Rhinolophus ferrumequinum	117032965	RHIFE24916
Scophthalmus maximus	118286131	SCOMX11614