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RAB7A, member RAS oncogene family

Summary

Gene Symbol

RAB7A

Organism

Homo sapiens (human)

External Links

NCBI Gene

7879

HGNC

9788

PubChem

7879

Alliance of Genome Resources

HGNC:9788

Annotation

Keyword

3D-structure
Acetylation
Autophagy
Charcot-Marie-Tooth disease
Cytoplasmic vesicle
Disease variant
Endosome
GTP-binding
Host-virus interaction
Hydrolase
Isopeptide bond
Lipid degradation
Lipid droplet
Lysosome
Membrane
Methylation
Mitochondrion
Neurodegeneration
Phosphoprotein
Prenylation
Protein transport
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P51149
A0A158RFU6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IMP	19956673
protein targeting to lysosome	IMP	22115783
endocytosis	TAS	2115402
epidermal growth factor catabolic process	IMP	18272684
endosome to lysosome transport	IMP	18272684

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

lipophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

lipophagy

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

membrane docking [inference]

protein to membrane docking

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

lipophagy

cellular localization [inference]

intracellular transport

intracellular protein transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

synaptic vesicle recycling via endosome

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy [inference]

lipophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

organelle assembly [inference]

autophagosome assembly

phagosome maturation

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

viral process [inference]

viral release from host cell

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

exit from host cell [inference]

viral release from host cell

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

synaptic vesicle recycling [inference]

synaptic vesicle recycling via endosome

intracellular transport

intracellular protein transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

synaptic vesicle recycling via endosome

organic substance transport [inference]

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

nitrogen compound transport [inference]

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization in cell [inference]

synaptic vesicle recycling [inference]

synaptic vesicle recycling via endosome

intracellular transport

intracellular protein transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

synaptic vesicle recycling via endosome

establishment of vesicle localization

establishment of organelle localization [inference]

establishment of vesicle localization

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization

establishment of organelle localization [inference]

establishment of vesicle localization

cellular localization [inference]

intracellular transport

intracellular protein transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

neurotransmitter receptor transport, postsynaptic endosome to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

retrograde transport, endosome to Golgi

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

synaptic vesicle recycling via endosome

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport

intracellular protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

negative regulation of intralumenal vesicle formation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of viral process

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of endosome organization [inference]

negative regulation of intralumenal vesicle formation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

negative regulation of intralumenal vesicle formation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of viral process [inference]

positive regulation of viral process

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of endosome organization [inference]

negative regulation of intralumenal vesicle formation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of endosome organization [inference]

negative regulation of intralumenal vesicle formation

regulation of endosome organization [inference]

negative regulation of endosome organization [inference]

negative regulation of intralumenal vesicle formation

regulation of intralumenal vesicle formation [inference]

negative regulation of intralumenal vesicle formation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of endosome organization [inference]

negative regulation of intralumenal vesicle formation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
autophagosome membrane	IEA
mitochondrion	IDA	34432599
lysosome	IDA	15078902 18272684
lysosome	IBA
lysosomal membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

retromer complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane

pigment granule membrane [inference]

melanosome membrane

mitochondrial membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane

pigment granule membrane [inference]

melanosome membrane

phagophore assembly site membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

intracellular non-membrane-bounded organelle [inference]

lipid droplet

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
GTPase activity	IDA	18272684
G protein activity	IEA
protein binding	IPI	14617358 15471887 15933719 16176980 16925951 18272684 18787122 20100911 22261744 22431521 24344282 25500191 26416964 26496610 26911690 27291868 28325809 30323948 30709847 30721249 32814053 33452816 33947832 33961781 34432599
GTP binding	IDA	18272684
GDP binding	IDA	18272684

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

retromer complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
GTP binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase

Human Protein Atlas

ENSG00000075785

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110159	Charcot-Marie-Tooth disease type 2B	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000763	Sensory neuropathy
HP:0001218	Autoamputation
HP:0001265	Hyporeflexia
HP:0001284	Areflexia
HP:0001761	Pes cavus
HP:0001763	Pes planus
HP:0001765	Hammertoe
HP:0001810	Dystrophic toenail
HP:0001868	Autoamputation of foot

Displaying 1 entry
Disease ID	Disease Name
OMIM:600882	Charcot-Marie-Tooth disease type 2B

PubChem Disease

MedGen Diseases

Charcot-Marie-Tooth disease type 2B

OMIM Phenotypes

CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B; CMT2B

KEGG Diseases

Charcot-Marie-Tooth disease

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7879	Xenbase:XB-GENE-483564
Mus musculus	19349		MOUSE47676
Rattus norvegicus	29448		RATNO31121
Danio rerio	393902		DANRE46922
Canis lupus familiaris	404007		CANLF07222
Pan troglodytes	470919		PANTR32122
Bos taurus	509970		BOVIN18133
Macaca mulatta	707280		MACMU28283
Oryctolagus cuniculus	100008682		RABIT12651
Monodelphis domestica	100017336		MONDO29834

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements